ArticleNucleic acids research2003
Functional conservation of Dhh1p, a cytoplasmic DExD/H-box protein present in large complexes.
Article in Nucleic acids research, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 39 citations in OpenAlex.
- Quantification of elongation stalls and impact on gene expression in yeast.RNA (New York, N.Y.) · 2023Article
- Quantification of elongation stalls and impact on gene expression in yeast.bioRxiv : the preprint server for biology · 2023Article
- Functional association of Loc1 and Puf6 with RNA helicase Dhh1 in translational regulation of Saccharomyces cerevisiae Ste12.PloS one · 2019Article
- Article
- Translational repression of theRNA (New York, N.Y.) · 2017Article
- Mutational analysis of the RNA helicase Dhh1 in Ste12 expression and yeast mating.Journal of microbiology (Seoul, Korea) · 2017Article
- A novel translational control mechanism involving RNA structures within coding sequences.Genome research · 2017Article
- Role of the DHH1 gene in the regulation of monocarboxylic acids transporters expression in Saccharomyces cerevisiae.PloS one · 2014Article
- The RNA helicase Dhh1p cooperates with Rbp1p to promote porin mRNA decay via its non-conserved C-terminal domain.Nucleic acids research · 2012Article
- The DExD/H box ATPase Dhh1 functions in translational repression, mRNA decay, and processing body dynamics.The Journal of cell biology · 2011Article
- Nutrients and the Pkh1/2 and Pkc1 protein kinases control mRNA decay and P-body assembly in yeast.The Journal of biological chemistry · 2011Article
- Tom20 mediates localization of mRNAs to mitochondria in a translation-dependent manner.Molecular and cellular biology · 2010Article
- Article
- The DEAD-box RNA helicase Ded1p affects and accumulates in Saccharomyces cerevisiae P-bodies.Molecular biology of the cell · 2008Article
- Ataxin-2 interacts with the DEAD/H-box RNA helicase DDX6 and interferes with P-bodies and stress granules.Molecular biology of the cell · 2007Article
- Xenopus Xp54 and human RCK/p54 helicases functionally replace yeast Dhh1p in brome mosaic virus RNA replication.Journal of virology · 2007Article
- Dead-box proteins: a family affair--active and passive players in RNP-remodeling.Nucleic acids research · 2006Review
- Xp54 and related (DDX6-like) RNA helicases: roles in messenger RNP assembly, translation regulation and RNA degradation.Nucleic acids research · 2006Review
- Article
- A role for the eIF4E-binding protein 4E-T in P-body formation and mRNA decay.The Journal of cell biology · 2005Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
The DHH1 gene in the yeast Saccharomyces cerevisiae encodes a putative RNA helicase of remarkable sequence similarity to several other DExD/H-box proteins, including Xp54 in Xenopus laevis and Ste13p in Schizosaccharomyces pombe. We show here that over-expression of Xp54, an integral component of the stored messenger ribonucleoprotein (mRNP) particles, can rescue the loss of Dhh1p in yeast. Localization and sedimentation studies showed that Dhh1p exists predominantly in the cytoplasm and is present in large complexes whose sizes appear to vary according to the growth stage of the cell culture. In addition, deletion of dhh1, when placed in conjunction with the mutant dbp5 and ded1 alleles, resulted in a synergistically lethal effect, suggesting that Dhh1p may have a role in mRNA export and translation. Finally, similar to Ste13p, Dhh1p is required for sporulation in the budding yeast. Taken together, our data provide evidence that the functions of Dhh1p are conserved through evolution.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.