ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2003
Apamin-sensitive small conductance calcium-activated potassium channels, through their selective coupling to voltage-gated calcium channels, are critical determinants of the precision, pace, and pattern of action potential generation in rat subthalamic nucleus neurons in vitro.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 80 papers.
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Who cites it
80 citing papers in PubMed, 210 citations in OpenAlex.
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- Model-based design of subthalamic nucleus neurons using hybrid optimization.Journal of neurophysiology · 2026Article
- Extended secondhand smoke exposure alters potassium channel activity and reduces excitability of cardiac vagal neurons in mice.Frontiers in physiology · 2026Article
- Neuropeptide-Dependent Spike Time Precision and Plasticity in Circadian Output Neurons.The European journal of neuroscience · 2025Article
- Computational model for control of hand movement in Parkinson's disease using deep brain stimulation.Experimental brain research · 2025Article
- Quantifying harmony between direct and indirect pathways in the basal ganglia: healthy and Parkinsonian states.Cognitive neurodynamics · 2024Article
- Break-up and recovery of harmony between direct and indirect pathways in the basal ganglia: Huntington's disease and treatment.Cognitive neurodynamics · 2024Article
- Evoked resonant neural activity long-term dynamics can be reproduced by a computational model with vesicle depletion.Neurobiology of disease · 2024Article
- Optimization of an anatomically and electrically detailed rodent subthalamic nucleus neuron model.Journal of neurophysiology · 2024Article
- Mathematical derivation and mechanism analysis of beta oscillations in a cortex-pallidum model.Cognitive neurodynamics · 2024Article
- Molecular and functional profiling of cell diversity and identity in the lateral superior olive, an auditory brainstem center with ascending and descending projections.Frontiers in cellular neuroscience · 2024Article
- Modulation of SK Channels via Calcium Buffering Tunes Intrinsic Excitability of Parvalbumin Interneurons in Neuropathic Pain: A Computational and Experimental Investigation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Altered neural cell junctions and ion-channels leading to disrupted neuron communication in Parkinson's disease.NPJ Parkinson's disease · 2022Review
- The theoretical mechanism of Parkinson's oscillation frequency bands: a computational model study.Cognitive neurodynamics · 2021Article
- Chronic unpredictable stress induces depression-related behaviors by suppressing AgRP neuron activity.Molecular psychiatry · 2021Article
- Sex-dependent alterations in the physiology of entorhinal cortex neurons in old heterozygous 3xTg-AD mice.Biology of sex differences · 2020Article
- Multistable properties of human subthalamic nucleus neurons in Parkinson's disease.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Nucleus accumbens shell small conductance potassium channels underlie adolescent ethanol exposure-induced anxiety.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019Article
- Maladaptive Downregulation of Autonomous Subthalamic Nucleus Activity following the Loss of Midbrain Dopamine Neurons.Cell reports · 2019Article
20 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Distinct activity patterns in subthalamic nucleus (STN) neurons are observed during normal voluntary movement and abnormal movement in Parkinson's disease (PD). To determine how such patterns of activity are regulated by small conductance potassium (SK)/calcium-activated potassium (KCa) channels and voltage-gated calcium (Cav) channels, STN neurons were recorded in the perforated patch configuration in slices, [which were prepared from postnatal day 16 (P16)-P30 rats and held at 37 degrees C] and then treated with the SK KCa channel antagonist apamin or the SK KCa channel agonist 1-ethyl-2-benzimidazolinone or the Cav channel antagonists w-omega-conotoxin GVIA (Cav2.2-selective) or nifedipine (Cav1.2-1.3-selective) [corrected]. In other experiments, fura-2 was introduced as an indicator of intracellular calcium dynamics. A component of the current underlying single-spike afterhyperpolarization was sensitive to apamin, phase-locked to calcium entry via Cav2.2 channels, and necessary for precise, autonomous, single-spike oscillation. SK KCa/Cav2.2 channel coupling did not underlie spike-frequency adaptation but limited activity in response to current injection by encoding the accumulation of intracellular calcium, maintained the characteristic sigmoidal frequency-intensity relationship and generated a post-train afterhyperpolarization. In addition, SK KCa channels terminated rebound burst activity more effectively in neurons with short-duration bursts (<100 msec) than neurons with long-duration bursts (>100 msec), presumably through their activation by Cav3 channels. Cav1.2-1.3 channels were not strongly coupled to SK KCa channels and therefore supported secondary range and long-duration rebound burst firing. In summary, SK KCa channels play a fundamental role in autonomous, driven, and rebound activity and oppose the transition from autonomous, rhythmic, single-spike activity to burst firing in STN neurons.
Indexed as
Identifiers
12930791PMC6740770W1823433896What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.