ArticleGenetics2003
Human population structure and its effects on sampling Y chromosome sequence variation.
Article in Genetics, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Ecological basis and genetic architecture of crypsis polymorphism in the desert clicker grasshopper (Ligurotettix coquilletti).Evolution; international journal of organic evolution · 2021Article
- Cultural Innovations Influence Patterns of Genetic Diversity in Northwestern Amazonia.Molecular biology and evolution · 2018Article
- Paleopathological Considerations on Malaria Infection in Korea before the 20th Century.BioMed research international · 2018Review
- Phylogeography of Pogonomyrmex barbatus and P. rugosus harvester ants with genetic and environmental caste determination.Ecology and evolution · 2015Article
- Moving forward: breaking the cycle of mistrust between American Indians and researchers.American journal of public health · 2013Article
- Population genetic structure of sexual and parthenogenetic damselflies inferred from mitochondrial and nuclear markers.Heredity · 2012Article
- Development of a single base extension method to resolve Y chromosome haplogroups in sub-Saharan African populations.Investigative genetics · 2010Article
- Article
- Molecular evolution of GYPC: evidence for recent structural innovation and positive selection in humans.Molecular biology and evolution · 2009Article
- The impact of sampling schemes on the site frequency spectrum in nonequilibrium subdivided populations.Genetics · 2009Article
- Evolution of a behavior-linked microsatellite-containing element in the 5' flanking region of the primate AVPR1A gene.BMC evolutionary biology · 2008Article
- New binary polymorphisms reshape and increase resolution of the human Y chromosomal haplogroup tree.Genome research · 2008Article
- Inferring human population sizes, divergence times and rates of gene flow from mitochondrial, X and Y chromosome resequencing data.Genetics · 2007Article
- Population structure and its effects on patterns of nucleotide polymorphism in teosinte (Zea mays ssp. parviglumis).Genetics · 2007Article
- Article
- The origin and age of Plasmodium vivax.Trends in parasitology · 2006Article
- Complete sequence data support lack of balancing selection on PRNP in a natural Chinese population.Journal of human genetics · 2006Article
- Dual origins of the Japanese: common ground for hunter-gatherer and farmer Y chromosomes.Journal of human genetics · 2006Article
- A comparison of variation between a MHC pseudogene and microsatellite loci of the little greenbul (Andropadus virens).BMC evolutionary biology · 2005Article
- Fitting background-selection predictions to levels of nucleotide variation and divergence along the human autosomes.Genome research · 2005Article
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Authors and funding
5 authors.
Funding
Abstract
The excess of rare variants in global sequencing studies of the nonrecombining portion of the Y chromosome (NRY) has been interpreted as evidence for the effects of human demographic expansion. However, many NRY polymorphisms are geographically localized and the effect of different geographical sampling on patterns of NRY variation is unknown. We use two sampling designs to detect population structure and its effects on patterns of human NRY polymorphism. First, we sequence 26.5 kb of noncoding Y chromosome DNA from 92 globally distributed males representing 35 populations. We find that the number of polymorphisms with singleton variants is positively correlated with the number of populations sampled and that there is a significant negative correlation of Tajima's D (TD) and Fu and Li's D (FD) statistics with the number of pooled populations. We then sequence the same region in a total of 73 males sampled from 3 distinct populations and find that TD and FD values for the 3 pooled and individual population samples were much less negative than those in the aforementioned global sample. Coalescent simulations show that a simple splitting model of population structure, with no changes in population size, is sufficient to produce the negative values of TD seen in our pooled samples. These empirical and simulation results suggest that observed levels of NRY population structure may lead to an upward bias in the number of singleton variants in global surveys and call into question inferences of population expansion based on global sampling strategies.
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