ArticleGenetics2003
Natural selection drives Drosophila immune system evolution.
Article in Genetics, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 110 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
110 citing papers in PubMed, 183 citations in OpenAlex.
- The evolution of the immune system of bees is defined by conservation, expansions, and losses.BMC biology · 2026Article
- Predictors of Protein Evolution in the drosophilid Immune System.Genome biology and evolution · 2026Article
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- Non-MHC immunity genes do not affect parasite load in European invasive populations of common raccoon.Scientific reports · 2023Article
- Evolutionary mechanisms underlying the diversification of nuclear factor of activated T cells across vertebrates.Scientific reports · 2023Article
- Complex patterns shape immune genes diversity during invasion of common raccoon in Europe - Selection in action despite genetic drift.Evolutionary applications · 2023Article
- Shared Patterns of Gene Expression and Protein Evolution Associated with Adaptation to Desert Environments in Rodents.Genome biology and evolution · 2022Article
- Dissecting Genomic Determinants of Positive Selection with an Evolution-Guided Regression Model.Molecular biology and evolution · 2022Article
- Molecular Evolution of Ecological Specialisation: Genomic Insights from the Diversification of Murine Rodents.Genome biology and evolution · 2021Article
- Intraspecific variation in immune gene expression and heritable symbiont density.PLoS pathogens · 2021Article
- Article
- Genomic analysis of the four ecologically distinct cactus host populations of Drosophila mojavensis.BMC genomics · 2019Article
- Adaptive Evolution Patterns in the Pacific Oyster Crassostrea gigas.Marine biotechnology (New York, N.Y.) · 2019Article
- Balancing Selection Drives the Maintenance of Genetic Variation in Drosophila Antimicrobial Peptides.Genome biology and evolution · 2019Article
- Insights into the Genomics of Clownfish Adaptive Radiation: Genetic Basis of the Mutualism with Sea Anemones.Genome biology and evolution · 2019Article
- Article
- Multiple Selection Signatures in Farmed Atlantic Salmon Adapted to Different Environments Across Hemispheres.Frontiers in genetics · 2019Article
- Review
- Review
- Detection of Regional Variation in Selection Intensity within Protein-Coding Genes Using DNA Sequence Polymorphism and Divergence.Molecular biology and evolution · 2017Article
50 more citing papers are in PubMed but not listed here.
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Evidence from disparate sources suggests that natural selection may often play a role in the evolution of host immune system proteins. However, there have been few attempts to make general population genetic inferences on the basis of analysis of several immune-system-related genes from a single species. Here we present DNA polymorphism and divergence data from 34 genes thought to function in the innate immune system of Drosophila simulans and compare these data to those from 28 nonimmunity genes sequenced from the same lines. Several statistics, including average K(A)/K(S) ratio, average silent heterozygosity, and average haplotype diversity, significantly differ between the immunity and nonimmunity genes, suggesting an important role for directional selection in immune system protein evolution. In contrast to data from mammalian immunoglobulins and other proteins, we find no strong evidence for the selective maintenance of protein diversity in Drosophila immune system proteins. This may be a consequence of Drosophila's generalized innate immune response.
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Registered trials
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