ArticleGenetics2003
Scribble is essential for olfactory behavior in Drosophila melanogaster.
Article in Genetics, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 33 citations in OpenAlex.
- Characterization of reproductive proteins in the Mexican fruit fly points towards the evolution of novel functions.Proceedings. Biological sciences · 2022Article
- Pilot RNAi Screen inInternational journal of molecular sciences · 2021Article
- Identification of quantitative trait loci associated with calmness and gentleness in honey bees using whole-genome sequences.Animal genetics · 2021Article
- Genetic Basis of Natural Variation in Spontaneous Grooming inG3 (Bethesda, Md.) · 2020Article
- The neuronal protein Neurexin directly interacts with the Scribble-Pix complex to stimulate F-actin assembly for synaptic vesicle clustering.The Journal of biological chemistry · 2017Article
- Article
- Genetic architecture of olfactory behavior in Drosophila melanogaster: differences and similarities across development.Behavior genetics · 2013Article
- Making scents of behavioural genetics: lessons from Drosophila.Genetics research · 2010Review
- Phenotypic plasticity and genotype by environment interaction for olfactory behavior in Drosophila melanogaster.Genetics · 2008Article
- Dynamic genetic interactions determine odor-guided behavior in Drosophila melanogaster.Genetics · 2006Article
- Drosophila bristles and the nature of quantitative genetic variation.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2005Review
- The tumor suppressor Scrib interacts with the zyxin-related protein LPP, which shuttles between cell adhesion sites and the nucleus.BMC cell biology · 2005Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The ability to discriminate and respond to chemical signals from the environment is an almost universal prerequisite for survival. Here, we report that the scaffold protein Scribble is essential for odor-guided behavior in Drosophila. Previously, we identified a P-element insert line with generalized sexually dimorphic smell impairment, smi97B. We found that the transposon in this line is located between the predicted promoter region and the transcription initiation site of scrib. A deficiency in this region, Df(3R)Tl-X, and two scrib null alleles fail to complement the smell-impaired phenotype of smi97B. Wild-type behavior is restored by precise excision of the P element, scrib mRNA levels correspond with mutant and wild-type phenotypes, and introduction of a full-length scrib transgene in the smi97B mutant rescues the olfactory deficit. Expression of Scrib is widespread in olfactory organs and the central nervous system. Finally, alternative splicing of scrib generates transcripts that differ in the number of leucine-rich repeats and PDZ domains.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.