ArticleGenetics2003
Identification and analysis of mutations in bob, Doa and eight new genes required for oocyte specification and development in Drosophila melanogaster.
Article in Genetics, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 32 citations in OpenAlex.
- SR Protein Kinase is expressed inmicroPublication biology · 2025Article
- Natural alleles at theProceedings. Biological sciences · 2022Article
- Coordinating Proliferation, Polarity, and Cell Fate in theFrontiers in cell and developmental biology · 2020Review
- Methods for studying oogenesis.Methods (San Diego, Calif.) · 2014Review
- A mosaic genetic screen for genes involved in the early steps of Drosophila oogenesis.G3 (Bethesda, Md.) · 2013Article
- Biogenesis of glutaminyl-mt tRNAGln in human mitochondria.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Article
- Article
- A maternal screen for genes regulating Drosophila oocyte polarity uncovers new steps in meiotic progression.Genetics · 2007Article
- The conserved kinase NHK-1 is essential for mitotic progression and unifying acentrosomal meiotic spindles in Drosophila melanogaster.The Journal of cell biology · 2005Article
- l(3)malignant brain tumor and three novel genes are required for Drosophila germ-cell formation.Genetics · 2003Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Drosophila oocyte develops from a cluster of 16 interconnected cells that derive from a common progenitor. One of these cells, the oocyte, arrests in meiosis. The other cells endoreplicate their DNA and produce mRNAs and proteins that they traffic to the oocyte along a polarized microtubule cytoskeleton shared by the entire cyst. Therefore, Drosophila oogenesis is an attractive system for the study of cell cycle control and cell polarity. We carried out a clonal screen on the right arm of chromosome 3 for female sterile mutations using the FLP-FRT-ovo(D) system to identify new genes required for early oogenesis. We identified alleles of oo18 RNA binding protein (orb) and Darkener of apricot (Doa), which had previously been shown to exhibit oogenesis defects. We also identified several lethal alleles of the male sterile mutant, bobble (bob). In addition, we identified eight new lethal complementation groups that exhibit early oogenesis phenotypes. We analyzed mutant clones to determine the aspects of oogenesis disrupted by each complementation group. We assayed for the production and development of egg chambers, localization of ORB to and within the oocyte, and proper execution of the nurse cell cycle (endoreplication of DNA) and the oocyte cell cycle (karyosome formation). Here we discuss the identification, mapping, and phenotypic characterization of these new genes: omelet, soft boiled, hard boiled, poached, fried, over easy, sunny side up, and benedict.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.