ArticleClinical and experimental immunology2003
Mimicry between the hepatitis C virus polyprotein and antigenic targets of nuclear and smooth muscle antibodies in chronic hepatitis C virus infection.
Article in Clinical and experimental immunology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 113 citations in OpenAlex.
- Hepatitis C Virus and Molecular Mimicry.Pathogens (Basel, Switzerland) · 2024Review
- Unraveling the intricate dance of the Mediterranean diet and gut microbiota in autoimmune resilience.Frontiers in nutrition · 2024Review
- Pathogenesis of Autoimmune Hepatitis-Cellular and Molecular Mechanisms.International journal of molecular sciences · 2021Review
- Negative conversion of autoantibody profile in chronic hepatitis B: A case report.World journal of clinical cases · 2021Article
- Impact of Antigen Presentation Mechanisms on Immune Response in Autoimmune Hepatitis.Frontiers in immunology · 2021Review
- Pathogens and autoimmune hepatitis.Clinical and experimental immunology · 2019Review
- Autoantibodies in chronic hepatitis C virus infection: impact on clinical outcomes and extrahepatic manifestations.BMJ open gastroenterology · 2018Article
- Anti-Ro60 Seropositivity Determines Anti-Ro52 Epitope Mapping in Patients With Systemic Sclerosis.Frontiers in immunology · 2018Article
- The Presence of Autoantibodies to Cytoplasmic Rod and Ring Particles in the Serum of Patients with Chronic Hepatitis C Virus Infection.Hepatitis monthly · 2016Article
- Lupus-like Immune Complex-mediated Glomerulonephritis in Patients with Hepatitis C Virus Infection Treated with Oral, Interferon-free, Direct-acting Antiviral Therapy.Kidney international reports · 2016Article
- Common molecular mechanism of the hepatic lesion and the cardiac parasympathetic regulation in chronic hepatitis C infection: a critical role for the muscarinic receptor type 3.BMC bioinformatics · 2016Article
- Autoimmune reactions in the course of the hepatitis C virus (HCV) infection.Clinical and experimental hepatology · 2015Review
- Helicobacter pylori and autoimmune disease: cause or bystander.World journal of gastroenterology · 2014Review
- Autoantibodies in liver disease: important clues for the diagnosis, disease activity and prognosis.Auto- immunity highlights · 2013Review
- Liver immunology.Comprehensive Physiology · 2013Review
- Clinical associations and potential novel antigenic targets of autoantibodies directed against rods and rings in chronic hepatitis C infection.BMC gastroenterology · 2013Article
- Autoimmune manifestations in viral hepatitis.Seminars in immunopathology · 2013Review
- Suspected and unsuspected factors in the multifaceted immunopathology of viral hepatitis.Seminars in immunopathology · 2013Article
- The immunopathogenetic role of autoantibodies in canine autoimmune hepatitis: lessons to learn from human autoimmune hepatitis.Auto- immunity highlights · 2012Review
- Predicting and preventing autoimmunity: the case of anti-mitochondrial antibodies.Auto- immunity highlights · 2012Review
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Autoantibodies to smooth muscle (SMA) and nuclear components (ANA) arise in the natural course of chronic infection with hepatitis C virus. In view of the growing evidence for 'molecular mimicry' as a mechanism of autoimmunity we investigated whether cross-reactive immune reactions between host smooth muscle/nuclear components and HCV antigens may contribute to the formation of SMA and ANA in chronic HCV infection. Computer-assisted protein database search methods were used to identify three smooth muscle (smoothelin698-717, myosin1035-1054, vimentin69-88) and three nuclear (matrin722-741, histone H2A11-30, replication protein A133-152) host antigens with the highest local sequence similarity to the HCV polyprotein and 20-mer peptides corresponding to these regions were constructed. Sera from 51 children with chronic HCV infection [median age: 8 (2-16); 27 boys], 26 SMA positive and five ANA positive, were tested for reactivity to the synthesized HCV peptides and their human homologues by enzyme linked immunosorbent assay (ELISA). Sera from patients with HBV infection and chronic liver disease of different aetiologies were used as controls. 'Double reactivity' to HCV peptides and smooth muscle/nuclear homologues was associated strongly with HCV infection (P < 0.001 for both). Humoral cross-reactivity was established as the basis for double recognition by competition ELISA. Double-reactivity to smooth muscle and HCV peptide antigens correlated with SMA positivity by indirect immunofluouresence (P = 0.05). Of 15 patients double-reactive to myosin1035-1054 and its HCV homologue, 13 recognized whole myosin by immunoblot. These results suggest that ANA and SMA in chronic HCV infection may arise, at least in part, as a consequence of cross-reactive immune responses to HCV and host smooth muscle/nuclear antigens.
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