ArticleAmerican journal of human genetics2003
Novel case-control test in a founder population identifies P-selectin as an atopy-susceptibility locus.
Article in American journal of human genetics, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 88 papers, 1 of them a synthesis that pooled it.
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Who cites it
88 citing papers in PubMed, 1 synthesis or guideline pooled it, 155 citations in OpenAlex.
- Genetic studies of stuttering in a founder population.Journal of fluency disorders · 2007Pooled it
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- A generalized robust allele-based genetic association test.Biometrics · 2022Article
- Potential Metabolic Biomarkers in Adult Asthmatics.Metabolites · 2021Review
- Estimating FST and kinship for arbitrary population structures.PLoS genetics · 2021Article
- Putative functional non-coding polymorphisms in SELP significantly modulate sP-selectin levels, arterial stiffness and type 2 diabetes mellitus susceptibility.BMC endocrine disorders · 2020Article
- Association score testing for rare variants and binary traits in family data with shared controls.Briefings in bioinformatics · 2019Article
- Variants regulating ZBTB4 are associated with age-at-onset of Alzheimer's disease.Genes, brain, and behavior · 2018Article
- L-GATOR: Genetic Association Testing for a Longitudinally Measured Quantitative Trait in Samples with Related Individuals.American journal of human genetics · 2018Article
- A Pragmatic Test for Detecting Association between a Dichotomous Trait and the Genotypes of Affected Families, Controls and Independent Cases.Frontiers in genetics · 2017Article
- CERAMIC: Case-Control Association Testing in Samples with Related Individuals, Based on Retrospective Mixed Model Analysis with Adjustment for Covariates.PLoS genetics · 2016Article
- Exome sequencing in an admixed isolated population indicates NFXL1 variants confer a risk for specific language impairment.PLoS genetics · 2015Article
- Family-based association analysis: a fast and efficient method of multivariate association analysis with multiple variants.BMC bioinformatics · 2015Article
- Parente2: a fast and accurate method for detecting identity by descent.Genome research · 2015Article
- Retrospective Association Analysis of Binary Traits: Overcoming Some Limitations of the Additive Polygenic Model.Human heredity · 2015Review
- Efficient generalized least squares method for mixed population and family-based samples in genome-wide association studies.Genetic epidemiology · 2014Article
- Article
- LEVERAGING LOCAL IDENTITY-BY-DESCENT INCREASES THE POWER OF CASE/CONTROL GWAS WITH RELATED INDIVIDUALS.The annals of applied statistics · 2014Article
- A statistical framework to guide sequencing choices in pedigrees.American journal of human genetics · 2014Article
28 more citing papers are in PubMed but not listed here.
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9 authors at 1 institution in 1 country.
Funding
Abstract
To avoid problems related to unknown population substructure, association studies may be conducted in founder populations. In such populations, however, the relatedness among individuals may be considerable. Neglecting such correlations among individuals can lead to seriously spurious associations. Here, we propose a method for case-control association studies of binary traits that is suitable for any set of related individuals, provided that their genealogy is known. Although we focus here on large inbred pedigrees, this method may also be used in outbred populations for case-control studies in which some individuals are relatives. We base inference on a quasi-likelihood score (QLS) function and construct a QLS test for allelic association. This approach can be used even when the pedigree structure is far too complex to use an exact-likelihood calculation. We also present an alternative approach to this test, in which we use the known genealogy to derive a correction factor for the case-control association chi2 test. We perform analytical power calculations for each of the two tests by deriving their respective noncentrality parameters. The QLS test is more powerful than the corrected chi2 test in every situation considered. Indeed, under certain regularity conditions, the QLS test is asymptotically the locally most powerful test in a general class of linear tests that includes the corrected chi2 test. The two methods are used to test for associations between three asthma-associated phenotypes and 48 SNPs in 35 candidate genes in the Hutterites. We report a highly significant novel association (P=2.10-6) between atopy and an amino acid polymorphism in the P-selectin gene, detected with the QLS test and also, but less significantly (P=.0014), with the transmission/disequilibrium test.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.