ArticleAmerican journal of human genetics2003
Genomewide linkage scan for schizophrenia susceptibility loci among Ashkenazi Jewish families shows evidence of linkage on chromosome 10q22.
Article in American journal of human genetics, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 1 of them a synthesis that pooled it.
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Who cites it
53 citing papers in PubMed, 1 synthesis or guideline pooled it, 105 citations in OpenAlex.
- Meta-analysis of 32 genome-wide linkage studies of schizophrenia.Molecular psychiatry · 2009Pooled it
- Effects of neuregulin 3 genotype on human prefrontal cortex physiology.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Trial
- Genetic investigation of chromosome 5q GABAA receptor subunit genes in schizophrenia.Molecular psychiatry · 2005Trial
- Genetic Variants from Large Cohorts and Familial Studies Implicate Common Mechanisms in Schizophrenia.Biology · 2026Review
- Genome-wide association reveals a locus in neuregulin 3 associated with gabapentin efficacy in women with chronic pelvic pain.iScience · 2024Article
- Genome-wide study of copy number variation implicates multiple novel loci for schizophrenia risk in Han Chinese family trios.iScience · 2021Article
- Neuregulin 3 rs10748842 polymorphism contributes to the effect of body mass index on cognitive impairment in patients with schizophrenia.Translational psychiatry · 2020Article
- Co-shared genetics and possible risk gene pathway partially explain the comorbidity of schizophrenia, major depressive disorder, type 2 diabetes, and metabolic syndrome.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2019Review
- Neuregulin 3 and its roles in schizophrenia risk and presentation.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2018Review
- Thorase variants are associated with defects in glutamatergic neurotransmission that can be rescued by Perampanel.Science translational medicine · 2017Article
- Temporal, Diagnostic, and Tissue-Specific Regulation of NRG3 Isoform Expression in Human Brain Development and Affective Disorders.The American journal of psychiatry · 2017Article
- Evidence for genetic regulation of the human parieto-occipital 10-Hz rhythmic activity.The European journal of neuroscience · 2016Article
- Neuregulin 3 Knockout Mice Exhibit Behaviors Consistent with Psychotic Disorders.Molecular neuropsychiatry · 2016Article
- Identification of genetic variants of LGI1 and RTN4R (NgR1) linked to schizophrenia that are defective in NgR1-LGI1 signaling.Molecular genetics & genomic medicine · 2016Article
- Factor structure of cognition and functional capacity in two studies of schizophrenia and bipolar disorder: Implications for genomic studies.Neuropsychology · 2016Article
- Improving the understanding of the link between cognition and functional capacity in schizophrenia and bipolar disorder.Schizophrenia research · 2015Article
- Identification and functional studies of regulatory variants responsible for the association ofMolecular neuropsychiatry · 2015Article
- Infection and inflammation in schizophrenia and bipolar disorder: a genome wide study for interactions with genetic variation.PloS one · 2015Article
- Role of the Neuregulin Signaling Pathway in Nicotine Dependence and Co-morbid Disorders.International review of neurobiology · 2015Review
- Functional variants in DPYSL2 sequence increase risk of schizophrenia and suggest a link to mTOR signaling.G3 (Bethesda, Md.) · 2014Article
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
Previous linkage studies in schizophrenia have been discouraging due to inconsistent findings and weak signals. Genetic heterogeneity has been cited as one of the primary culprits for such inconsistencies. We have performed a 10-cM autosomal genomewide linkage scan for schizophrenia susceptibility regions, using 29 multiplex families of Ashkenazi Jewish descent. Although there is no evidence that the rate of schizophrenia among the Ashkenazim differs from that in other populations, we have focused on this population in hopes of reducing genetic heterogeneity among families and increasing the detectable effects of any particular locus. We pursued both allele-sharing and parametric linkage analyses as implemented in Genehunter, version 2.0. Our strongest signal was achieved at chromosome 10q22.3 (D10S1686), with a nonparametric linkage score (NPL) of 3.35 (genomewide empirical P=.035) and a dominant heterogeneity LOD score (HLOD) of 3.14. Six other regions gave NPL scores >2.00 (on chromosomes 1p32.2, 4q34.3, 6p21.31, 7p15.2, 15q11.2, and 21q21.2). Upon follow-up with an additional 23 markers in the chromosome 10q region, our peak NPL score increased to 4.27 (D10S1774; empirical P=.00002), with a 95% confidence interval of 12.2 Mb for the location of the trait locus (D10S1677 to D10S1753). We find these results encouraging for the study of schizophrenia among Ashkenazi families and suggest further linkage and association studies in this chromosome 10q region.
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