Evidence map›Paper›PMID 12928750›Full record

ArticleCurrent genetics2003

Cryptosporidium parvum Cpn60 targets a relict organelle.

Christina E Riordan, Jeffrey G Ault, Susan G Langreth, Janet S Keithly

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in Current genetics, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
6.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 82 citations in OpenAlex.

  1. The history of cryptosporidiosis.Parasites & vectors · 2026
    Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. The apicoplast: now you see it, now you don't.International journal for parasitology · 2017
    Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Diversity and reductive evolution of mitochondria among microbial eukaryotes.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2010
    Review
  15. Review
  16. Review
  17. Article
  18. Article
  19. Multiple secondary origins of the anaerobic lifestyle in eukaryotes.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2006
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Christina E RiordanWadsworth Center, New York State Department of Health, Axelrod Institute for Public Health, 120 New Scotland Avenue, Albany, NY 12208, USA.
Jeffrey G Ault
Susan G Langreth
Janet S Keithly
New York State Department of Health · USUniformed Services University of the Health Sciences · USUniversity at Albany, State University of New York · US

Funding

DRUG DISCOVERY--POLYAMINE METABOLISM OF CRYPTOSPORIDIUMU01AI040320 · NIAID · WADSWORTH CENTER · PI KEITHLY, JANET S. · 1996 to 1999
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NIAID NIH HHS AI 40320
6 · The paper itself

Abstract

Chaperonin 60 (Cpn60) is a well-established marker protein for eukaryotic mitochondria and plastids. In order to determine whether the small double-membrane-bounded organelle posterior to the nucleus in the apicomplexan Cryptosporidium parvum is a mitochondrion, the Cpn60 gene of C. parvum sporozoites ( CpCpn60) was analyzed and antibodies were generated for localization of the peptide. Sequence and phylogenetic analyses indicated that CpCpn60 is a mitochondrial isotype and that antibodies against it localize to the rough endoplasmic reticulum-enveloped remnant organelle of C. parvum sporozoites. These data show this organelle is of mitochondrial origin.

Indexed as

Amino Acid SequenceAnimalsBlotting, SouthernBlotting, WesternChaperonin 60Cluster AnalysisCryptosporidium parvumDNA PrimersEnzyme-Linked Immunosorbent AssayGene LibraryGreen Fluorescent ProteinsImmune SeraImmunohistochemistryLikelihood FunctionsLuminescent ProteinsMicroscopy, ElectronChaperonin 60DNA PrimersGreen Fluorescent ProteinsImmune SeraLuminescent Proteins

Identifiers

PMID12928750
OpenAlexW1976550174

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.