ArticleJournal of cellular and molecular medicine
Mast cells in tissue response to dentistry materials: an adhesive resin, a calcium hydroxide and a glass ionomer cement.
Article in Journal of cellular and molecular medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 41 citations in OpenAlex.
- Inorganic materials to prevent liquefactive necrosis and improve wound healing: A role of infection control across ischemic models.Materials today. Bio · 2026Article
- Histocompatibility of Dental Restorative Composite Resin Photopolymerized with a Novel Multifunctional Comonomer: A Histopathological Analysis in Rats.Journal of pharmacy & bioallied sciences · 2021Article
- Review
- In vitro and in vivo evaluation of silicated hydroxyapatite and impact of insulin adsorption.Journal of materials science. Materials in medicine · 2014Article
- Reaction of rat subcutaneous connective tissue to resin composites polymerized with different light curing units and different lightening methods.International journal of dentistry · 2012Article
- In vitro and in vivo studies on the toxicity of dental resin components: a review.Clinical oral investigations · 2008Review
- Role of mast cells in wound healing process after glass-fiber composite implant in rats.Journal of cellular and molecular medicineArticle
- Biocompatibility of orthodontic adhesives in rat subcutaneous tissue.Journal of applied oral science : revista FOBArticle
- Use of a magnesium-based bone adhesive for flexor tendon-to-bone healing.The Journal of hand surgeryArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Synthetic materials used in dentistry may trigger various inflammatory responses. In order to evaluate biocompatibility, standardized implants of Calcium Hydroxide (CH), Glass Ionomer Cement (GIC) and Light-activated Dental Adhesive (LDA) were surgically introduced into Wistar rats' back bone. Six (experimental) animal groups, five each, and two Sham (S) groups were studied after 15 and 30 days from surgery. In each animal, the density of mast cells and interstitial fibrosis volume was evaluated by quantitative light microscopy. In addition, the interaction between the disk material and its fibrous capsule was evaluated by scanning electron microscopy. The density of mast cells per area (N(A)[mast cells]) was lower in CH group than in LDA group. GIC group displayed N(A)[mast cells] results intermediate between CH and LDA groups (p<0.05). The smallest interstitial fibrosis volume density (Vv[f]) was observed in CH group, then in GIC group, while the greatest in LDA group. After 30 days, the fibrosis in LDA group was 30% higher than in CH group (p<0.05). In S group, discreet fibrosis restricted to surgical area was present, with few mast cells near the vessels. Significant interaction between fibrous capsule and the surrounding disk material was most evident in CH group. The implanted materials induced mast cell migration, distinct fibrosis development, suggesting that CH is the most biocompatible material among those tested.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.