ArticleJournal of cellular and molecular medicine
Synergistic effects of neurons and astrocytes on the differentiation of brain capillary endothelial cells in culture.
Article in Journal of cellular and molecular medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 91 citations in OpenAlex.
- Article
- HumanTissue barriers · 2024Review
- Effects of Cerebrospinal Fluids from Alzheimer and Non-Alzheimer Patients on Neurons-Astrocytes-Microglia Co-Culture.International journal of molecular sciences · 2024Article
- Involvement of Astrocytes in the Formation, Maintenance, and Function of the Blood-Brain Barrier.Cells · 2024Review
- The role of the blood-brain barrier during neurological disease and infection.Biochemical Society transactions · 2023Review
- Vascularizing the brainiScience · 2022Review
- The Blood-Brain Barrier: Much More Than a Selective Access to the Brain.Neurotoxicity research · 2021Review
- From adsorption to covalent bonding: Apolipoprotein E functionalization of polymeric nanoparticles for drug delivery across the blood-brain barrier.Advanced therapeutics · 2021Article
- Article
- A 3D‑scaffold of PLLA induces the morphological differentiation and migration of primary astrocytes and promotes the production of extracellular vesicles.Molecular medicine reports · 2019Article
- Established and Emerging Strategies for Drug Delivery Across the Blood-Brain Barrier in Brain Cancer.Pharmaceutics · 2019Review
- Studying Human Neurological Disorders Using Induced Pluripotent Stem Cells: From 2D Monolayer to 3D Organoid and Blood Brain Barrier Models.Comprehensive physiology · 2019Review
- Human pluripotent stem cell-derived brain pericyte-like cells induce blood-brain barrier properties.Science advances · 2019Article
- Development of a direct contact astrocyte-human cerebral microvessel endothelial cells blood-brain barrier coculture model.The Journal of pharmacy and pharmacology · 2017Article
- An isogenic blood-brain barrier model comprising brain endothelial cells, astrocytes, and neurons derived from human induced pluripotent stem cells.Journal of neurochemistry · 2017Article
- Aquaporins and Brain Tumors.International journal of molecular sciences · 2016Review
- Role of Microvascular Disruption in Brain Damage from Traumatic Brain Injury.Comprehensive Physiology · 2015Review
- Melanoma cells homing to the brain: an in vitro model.BioMed research international · 2015Article
- Extracellular Membrane Vesicles as Vehicles for Brain Cell-to-Cell Interactions in Physiological as well as Pathological Conditions.BioMed research international · 2015Review
- Cell-culture models of the blood-brain barrier.Stroke · 2014Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Brain capillary endothelial cells form a functional barrier between blood and brain, based on the existence of tight junctions that limit paracellular permeability. Occludin is one of the major transmembrane proteins of tight junctions and its peripheral localization gives indication of tight junction formation. We previously reported that RBE4.B cells (brain capillary endothelial cells), cultured on collagen IV, synthesize occludin and correctly localize it at the cell periphery only when cocultured with neurons. In the present study, we describe a three-cell type-culture system that allowed us to analyze the combined effects of neurons and astrocytes on differentiation of brain capillary endothelial cells in culture. In particular, we found that, in the presence of astrocytes, the neuron-induced synthesis and localization of occludin is precocious as compared to cells cocultured with neurons only.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.