ReviewJournal of cellular and molecular medicine
Inflammatory mechanisms associated with brain damage induced by kainic acid with special reference to the interleukin-1 system.
Review in Journal of cellular and molecular medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.
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Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it, 102 citations in OpenAlex.
- Tualang Honey: A Decade of Neurological Research.Molecules (Basel, Switzerland) · 2021Pooled it
- Commonalities in gene expression and methylation changes across two rat models of acquired epilepsy.Scientific reports · 2026Article
- Effects of Troxerutin on Oxidative Stress, Inflammation and Galectin- 3 Expression in Intracerebroventricular Kainic Acid-Induced Neurotoxicity.Inflammation · 2025Article
- The Potential Role of Polyamines in Epilepsy and Epilepsy-Related Pathophysiological Changes.Biomolecules · 2022Review
- GPR120 modulates epileptic seizure and neuroinflammation mediated by NLRP3 inflammasome.Journal of neuroinflammation · 2022Article
- Neuroprotective effects of Lippia javanica (Burm.F.) Spreng. Herbal tea infusion on Lead-induced oxidative brain damage in Wistar rats.BMC complementary medicine and therapies · 2022Article
- Time and age dependent regulation of neuroinflammation in a rat model of mesial temporal lobe epilepsy: Correlation with human data.Frontiers in cell and developmental biology · 2022Article
- Honey on brain health: A promising brain booster.Frontiers in aging neuroscience · 2022Review
- Pretreatment with Methylene Blue Protects Against Acute Seizure and Oxidative Stress in a Kainic Acid-Induced Status Epilepticus Model.Medical science monitor : international medical journal of experimental and clinical research · 2021Article
- A comparative study of the phenotype with kainic acid-induced seizure in DBA/2 mice from three different sources.Laboratory animal research · 2020Article
- Article
- Overexpression of zinc-α2-glycoprotein suppressed seizures and seizure-related neuroflammation in pentylenetetrazol-kindled rats.Journal of neuroinflammation · 2018Article
- Tualang Honey Reduced Neuroinflammation and Caspase-3 Activity in Rat Brain after Kainic Acid-Induced Status Epilepticus.Evidence-based complementary and alternative medicine : eCAM · 2018Article
- Inflammation in epileptogenesis after traumatic brain injury.Journal of neuroinflammation · 2017Review
- Effect of Lead (Pb) on Inflammatory Processes in the Brain.International journal of molecular sciences · 2016Review
- Immunity and Inflammation in Epilepsy.Cold Spring Harbor perspectives in medicine · 2015Review
- Kainic Acid-Induced Excitotoxicity Experimental Model: Protective Merits of Natural Products and Plant Extracts.Evidence-based complementary and alternative medicine : eCAM · 2015Review
- The role of inflammation in epileptogenesis.Neuropharmacology · 2013Review
- From single-SNP to wide-locus: genome-wide association studies identifying functionally related genes and intragenic regions in small sample studies.Pharmacogenomics · 2013Article
- An adeno-associated virus-based intracellular sensor of pathological nuclear factor-κB activation for disease-inducible gene transfer.PloS one · 2013Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The evidence of inflammatory processes in the clinical manifestations and neuropathological sequelae of epilepsy have accumulated in the last decade. Administration of kainic acid, an analogue of the excitatory amino acid glutamate, induces a characteristic behavioural syndrome and a reproducible pattern of neurodegeneration in several brain areas, closely resembling human temporal lobe epilepsy. Results from studies using the kainic acid model indicate that manipulation of pro- and anti-inflammatory cytokines can modify the outcome with regard to the behavioural syndrome as well as the neuropathological consequences. Interleukin-1 is one of the most important cytokines and has several actions in the brain that are critical for the host defense against injury and infection, and it is involved in the initiation of early stages of inflammation. It is believed that interleukin-1 plays a pivotal role in the neuroinflammation associated with certain forms of neurodegeneration, including cerebral ischemia, trauma and excitotoxic brain injury. In this review, we have summarized the experimental data available with regard to the involvement of the interleukin-1 system in kainic acid-induced changes in the brain and emphasized the modulatory role of interleukin-1beta in this model of epilepsy
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.