ArticleBreast cancer research : BCR2003
BRCA2 mutation carriers, reproductive factors and breast cancer risk.
Article in Breast cancer research : BCR, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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24 citing papers in PubMed, 58 citations in OpenAlex.
- Natural menopause, menarche and breast cancer risk in BRCA1 and BRCA2 pathogenic variant carriers: a Mendelian randomization analysis.British journal of cancer · 2026Article
- Pregnancy after breast cancer: latest evidence and practical considerations.Therapeutic advances in medical oncology · 2025Review
- Cancer Is Associated with the Emergence of Placenta-Reactive Autoantibodies.Biomedicines · 2023Article
- A bibliometric analysis of the top 100 most cited papers and research trends in breast cancer related BRCA1 and BRCA2 genes.Medicine · 2022Article
- A human breast atlas integrating single-cell proteomics and transcriptomics.Developmental cell · 2022Article
- Reproductive factors as risk modifiers of breast cancer inOncotarget · 2017Article
- Oestrogen receptor status, treatment and breast cancer prognosis in Icelandic BRCA2 mutation carriers.British journal of cancer · 2016Article
- Iceland-genetic counseling services.Journal of genetic counseling · 2013Article
- BRCA1 and BRCA2 mutations and female fertility.Current opinion in obstetrics & gynecology · 2013Review
- BRCA1/2 mutations, fertility and the grandmother effect.Proceedings. Biological sciences · 2012Article
- Variation in breast cancer risk associated with factors related to pregnancies according to truncating mutation location, in the French National BRCA1 and BRCA2 mutations carrier cohort (GENEPSO).Breast cancer research : BCR · 2012Article
- Oophorectomy after menopause and the risk of breast cancer in BRCA1 and BRCA2 mutation carriers.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2012Article
- Pregnancy after Breast Cancer: Myths and Facts.Breast care (Basel, Switzerland) · 2012Article
- Effects of BRCA1 and BRCA2 mutations on female fertility.Proceedings. Biological sciences · 2012Article
- Breastfeeding and the risk of breast cancer in BRCA1 and BRCA2 mutation carriers.Breast cancer research : BCR · 2012Article
- Evaluation of established breast cancer risk factors as modifiers of BRCA1 or BRCA2: a multi-center case-only analysis.Breast cancer research and treatment · 2010Article
- Reproductive factors and risk of contralateral breast cancer by BRCA1 and BRCA2 mutation status: results from the WECARE study.Cancer causes & control : CCC · 2010Article
- Breast cancer and pregnancy: current concepts in diagnosis and treatment.The oncologist · 2010Review
- Lactation and incidence of premenopausal breast cancer: a longitudinal study.Archives of internal medicine · 2009Article
- Pregnancy and breast cancer: when they collide.Journal of mammary gland biology and neoplasia · 2009Review
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGermline mutations in the BRCA genes dramatically increase the risk of breast cancer. In the general population, breast cancer risk is affected by age at menarche, by age at first birth, by the number of births and by the duration of breast feeding. Whether this is true for mutation carriers is not clear.
methodsIn a case-control study, nested in a population-based cohort of the Icelandic Cancer Detection Clinic, two groups of cases were defined, matched on year of birth, on age at diagnosis and on age when giving information on reproductive factors: 100 carriers of the Icelandic founder BRCA2 mutation 999del5, and 361 BRCA2-negative cases. The mean age at diagnosis was 48 years. There were 1000 women in a matched group of unaffected controls. Conditional logistic regression was used for the analysis.
resultsAn increased number of births was associated with a decreased risk of breast cancer in BRCA2-negative cases but not in BRCA2-positive cases. A negative association between risk and duration of breast feeding was observed only in the mutation carriers. These associations were not statistically significant, but the effects of the two variables differed significantly according to mutation status (P = 0.007 and P = 0.045 for interaction with number of births and with duration of breast feeding, respectively). This was maintained when limiting the analysis to women diagnosed older than the age of 40 years.
conclusionThe association between breast cancer and the number of pregnancies and between breast cancer and the duration of breast feeding was not the same for carriers and noncarriers of a detrimental BRCA2 mutation. In the context of other epidemiological and laboratory studies, this may indicate that the product of the BRCA2 gene has a function relating to the differentiation of epithelial tissue in the breast.
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