ArticleAnticancer research
Matrix-dependent plasticity of the malignant phenotype of bladder cancer cells.
Article in Anticancer research. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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Who cites it
21 citing papers in PubMed, 36 citations in OpenAlex.
- Mechanisms and implications of epithelial cell plasticity in the bladder.Nature reviews. Urology · 2026Review
- Article
- Pancreatic Ductal Adenocarcinoma Cortical Mechanics and Clinical Implications.Frontiers in oncology · 2022Review
- Esophageal extracellular matrix hydrogel mitigates metaplastic change in a dog model of Barrett's esophagus.Science advances · 2020Article
- Extracellular Matrix Degradation Products Downregulate Neoplastic Esophageal Cell Phenotype.Tissue engineering. Part A · 2019Article
- Bioengineered models to study tumor dormancy.Journal of biological engineering · 2019Review
- Identification of novel drugs to target dormant micrometastases.BMC cancer · 2015Article
- [Tumour-stroma interactions in urothelial cancer].Der Urologe. Ausg. A · 2015Review
- Extracellular matrix heterogeneity regulates three-dimensional morphologies of breast adenocarcinoma cell invasion.Advanced healthcare materials · 2013Article
- Downregulation of Ral GTPase-activating protein promotes tumor invasion and metastasis of bladder cancer.Oncogene · 2013Article
- Article
- Biochemical and biomechanical characterization of porcine small intestinal submucosa (SIS): a mini review.International journal of burns and trauma · 2013Review
- A synthetic matrix with independently tunable biochemistry and mechanical properties to study epithelial morphogenesis and EMT in a lung adenocarcinoma model.Cancer research · 2012Article
- Dual sources of vitronectin in the human lower urinary tract: synthesis by urothelium vs. extravasation from the bloodstream.American journal of physiology. Renal physiology · 2011Article
- Small intestinal submucosa gel as a potential scaffolding material for cardiac tissue engineering.Acta biomaterialia · 2010Article
- Does the biomarker search paradigm need re-booting?BMC urology · 2009Article
- From microarray to biology: an integrated experimental, statistical and in silico analysis of how the extracellular matrix modulates the phenotype of cancer cells.BMC bioinformatics · 2008Article
- Proteome-level display by 2-dimensional chromatography of extracellular matrix-dependent modulation of the phenotype of bladder cancer cells.Proteome science · 2006Article
- Analysis of the interaction of extracellular matrix and phenotype of bladder cancer cells.BMC cancer · 2006Article
- Template-driven gene selection procedure.Systems biology · 2006Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
The purpose of this study was to investigate the effect of cancer- and normal basement membrane-derived extracellular matrix to modulate the phenotype of bladder cancer cell lines. Five lines, varying in malignancy from papilloma to highly undifferentiated and invasive and immortalized human urothelial cells, were grown on two extracellular matrix preparations, Matrigel and SISgel. Matrigel represents matrix remodeled by malignancy while SISgel, obtained from small intestine submucosa (SIS), represents the normal matrix supporting differentiated cell growth. On Matrigel, regardless of the content of growth factors, the invasive lines displayed an invasive phenotype, while the low grade lines grew as papillary structures. In contrast, when the same cells were grown on SISgel, they grew as a layer of cells one to 5 cells thick, failed to invade, and expressed cell-surface E-cadherin. Unlike breast cancer cells, neutralization of beta 1, beta 4 and alpha 6 integrins altered cell-cell and cell-matrix adhesiveness but did not alter the phenotype. When invasive cells were grown on mixtures of SISgel and Matrigel, the phenotype changed gradually, not abruptly, indicating that factors within the gel reversibly alter the phenotypic expression of invasion. In summary, the phenotype of bladder cancer cells growing in tissue-like 3-dimensional culture is highly plastic, and malignant properties such as invasion and papillary growth can be suppressed by the matrix.
Indexed as
Identifiers
12926044PMC2561328W1778790658What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.