ArticleMammalian genome : official journal of the International Mammalian Genome Society2003
Genetic loci for diet-induced atherosclerotic lesions and plasma lipids in mice.
Article in Mammalian genome : official journal of the International Mammalian Genome Society, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed.
- Article
- Genetic Evidence for a Causal Relationship between Hyperlipidemia and Type 2 Diabetes in Mice.International journal of molecular sciences · 2022Article
- Genetic determinants of susceptibility to silver nanoparticle-induced acute lung inflammation in mice.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2017Article
- Article
- Article
- Article
- ATR-FTIR spectroscopy reveals genomic loci regulating the tissue response in high fat diet fed BXD recombinant inbred mouse strains.BMC genomics · 2013Article
- Recalculation of 23 mouse HDL QTL datasets improves accuracy and allows for better candidate gene analysis.Journal of lipid research · 2013Article
- The systems genetics resource: a web application to mine global data for complex disease traits.Frontiers in genetics · 2013Article
- Establishment of consomic strains derived from A/J and SM/J mice for genetic analysis of complex traits.Mammalian genome : official journal of the International Mammalian Genome Society · 2012Article
- Differences in health status affect susceptibility and mapping of genetic loci for atherosclerosis (fatty streak) in inbred mice.Arteriosclerosis, thrombosis, and vascular biology · 2012Article
- High-resolution association mapping of atherosclerosis loci in mice.Arteriosclerosis, thrombosis, and vascular biology · 2012Article
- Genetics of atherosclerosis.Trends in genetics : TIG · 2012Review
- Genome-wide association mapping of quantitative traits in outbred mice.G3 (Bethesda, Md.) · 2012Article
- Genetic basis of atherosclerosis: insights from mice and humans.Circulation research · 2012Review
- Detection of quantitative trait loci affecting serum cholesterol, LDL, HDL, and triglyceride in pigs.BMC genetics · 2011Article
- Epistasis contributes to the genetic buffering of plasma HDL cholesterol in mice.Physiological genomics · 2010Article
- Four additional mouse crosses improve the lipid QTL landscape and identify Lipg as a QTL gene.Journal of lipid research · 2009Article
- Novel ENU-induced point mutation in scavenger receptor class B, member 1, results in liver specific loss of SCARB1 protein.PloS one · 2009Article
- Genetic dissection of the mouse brain using high-field magnetic resonance microscopy.NeuroImage · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
Genetic factors independent of those affecting plasma lipid levels are a major contributor to risk for atherosclerosis in humans, yet the basis for these is poorly understood. This study examined plasma lipids and diet-induced atherosclerosis in 16-month-old female mice of strains C56BL/6J and DBA/2J. Mice of the parental strains, from recombinant inbred strains derived from these (BXD RI), and F(2) progeny were fed an atherogenic diet for 16 weeks, beginning at 1 year of age. This induced atherosclerotic lesion formation in both parental strains, accompanied by increased plasma LDL levels. However, individual BXD RI strains and the BXD F(2) mice demonstrated a range of atherosclerotic lesion formation that was not or at best weakly correlated with plasma lipid levels. Quantitative trait locus (QTL) analysis of the BXD F(2) mice identified a locus with significant linkage (lod 4.5) for aortic lesion size on Chromosome (Chr) 10 that was independent of plasma lipids. Other loci with suggestive or significant linkage for various plasma lipid measures were identified on Chr 2, 3, 4, 5, 6, 7, 11, and 17. In this intercross, the genes primarily influencing atherosclerosis are distinct from those controlling plasma lipid levels.
Indexed as
Identifiers
12925895What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.