ArticleMammalian genome : official journal of the International Mammalian Genome Society2003
Two ENU-induced mutations in Rasgrf1 and early mouse growth retardation.
Article in Mammalian genome : official journal of the International Mammalian Genome Society, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 34 citations in OpenAlex.
- Viable offspring derived from single unfertilized mammalian oocytes.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Genomic imprinting and its effects on postnatal growth and adult metabolism.Cellular and molecular life sciences : CMLS · 2019Review
- DNA methylation analysis and editing in single mammalian oocytes.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- The role of genomic imprinting in biology and disease: an expanding view.Nature reviews. Genetics · 2014Review
- Rho guanine nucleotide exchange factors: regulators of Rho GTPase activity in development and disease.Oncogene · 2014Review
- Perturbations to the IGF1 growth pathway and adult energy homeostasis following disruption of mouse chromosome 12 imprinting.Acta physiologica (Oxford, England) · 2014Article
- Imprinted Rasgrf1 expression in neonatal mice affects olfactory learning and memory.Genes, brain, and behavior · 2011Article
- Regulation of Neuronal Function by Ras-GRF Exchange Factors.Genes & cancer · 2011Article
- RasGrf1 deficiency delays aging in mice.Aging · 2011Article
- Mice Lacking Ras-GRF1 Show Contextual Fear Conditioning but not Spatial Memory Impairments: Convergent Evidence from Two Independently Generated Mouse Mutant Lines.Frontiers in behavioral neuroscience · 2011Article
- Ras-guanine nucleotide-releasing factor 1 (Ras-GRF1) controls activation of extracellular signal-regulated kinase (ERK) signaling in the striatum and long-term behavioral responses to cocaine.Biological psychiatry · 2009Article
- Effects of ooplasm manipulation on DNA methylation and growth of progeny in mice.Biology of reproduction · 2009Article
- Interactions between imprinting effects in the mouse.Genetics · 2004Article
- Imprint switch mutations at Rasgrf1 support conflict hypothesis of imprinting and define a growth control mechanism upstream of IGF1.Mammalian genome : official journal of the International Mammalian Genome SocietyArticle
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
When paternally transmitted, two independent ENU-induced mutations showed reduced whole body wet weight soon after birth. The mutations were mapped to Chromosome 9 (Chr 9) between the markers D9Mit208 and D9Mit215. Their map position and imprinted status suggested that they might alter RAS protein-specific guanine nucleotide releasing factor 1 expression. Both mutations introduced premature chain termination codons into the coding sequence of Rasgrf1, and no Ras-GRF1 protein was detected in the brain. The GENA53 line had a C to T transition at nucleotide 2137, and the line GENA37 had a T to A transversion at nucleotide 3552 of the cDNA sequence. Mutant mice had near normal body weight at birth, but their weight started to lag behind that of wild-type littermates during the first week, and they were about 15% lighter as adults.
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