Evidence map›Paper›PMID 12925877›Full record

ArticleMedical microbiology and immunology2004

Coxsackievirus replication and the cell cycle: a potential regulatory mechanism for viral persistence/latency.

Ralph Feuer, Ignacio Mena, Robb R Pagarigan, Daniel E Hassett, J Lindsay Whitton

Abstract read
PubMed Publisher
In one paragraph

Article in Medical microbiology and immunology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 36 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Enterovirus and Encephalitis.Frontiers in microbiology · 2020
    Review
  5. Article
  6. Article
  7. The anti-obesity drug orlistat reveals anti-viral activity.Medical microbiology and immunology · 2015
    Article
  8. Review
  9. Article
  10. Article
  11. Human enterovirus species B in ileocecal Crohn's disease.Clinical and translational gastroenterology · 2013
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Coxsackievirus targets proliferating neuronal progenitor cells in the neonatal CNS.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2005
    Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Ralph FeuerDepartment of Neuropharmacology, CVN-9, The Scripps Research Institute, 10550 N. Torrey Pines Rd., La Jolla, CA 92037, USA.
Ignacio Mena
Robb R Pagarigan
Daniel E Hassett
J Lindsay Whitton
Scripps Research Institute · US

Funding

COXSACKIE MYOCARDITIS AND VIRAL PERSISTENCE IN THE HEARTR01AI042314 · NIAID · SCRIPPS RESEARCH INSTITUTE, THE · PI WHITTON, J. LINDSAY · 1998 to 2013
$5.6M
COXSACKIEVIRUS 3B PERSISTENCE AND REACTIVATION IN VIVOF32HL010490 · NHLBI · SCRIPPS RESEARCH INSTITUTE · PI FEUER, RALPH · 2001 to 2003
$127k
NHLBI NIH HHS F32 HL-10490NIAID NIH HHS R-01 AI-42314
6 · The paper itself

Abstract

Coxsackieviruses (CV) are characterized by their ability to cause cytopathic effects in tissue culture and by their capacity to initiate acute disease by inducing apoptosis within targeted organs in vivo. These viruses are considered highly cytolytic, but can establish persistence/latency in susceptible cells, indicating that a regulatory mechanism may exist to shut off viral protein synthesis and replication under certain situations. The persistence of coxsackieviral RNA is of particular medical interest due to its association with chronic human diseases such as dilated cardiomyopathy and chronic inflammatory myopathy. Here, we discuss the potential mechanisms regulating coxsackievirus replication, and the ability of viral RNA to remain in an apparent latent state within quiescent cells.

Indexed as

Gene Expression RegulationVirus LatencyVirus ReplicationAnimalsAnimals, NewbornBrainCell CycleEnterovirus B, HumanEnterovirus InfectionsGreen Fluorescent ProteinsHeLa CellsHumansLuminescent ProteinsMiceViral ProteinsGreen Fluorescent ProteinsLuminescent ProteinsViral Proteins

Identifiers

PMID12925877
OpenAlexW2013737543

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.