ArticleMolecular biology of the cell2003
Conservation of the prion properties of Ure2p through evolution.
Article in Molecular biology of the cell, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed.
- The p53 DNA-Binding (Core) Domain can form a prion that seeds prion formation in full-length p53.Microbial cell (Graz, Austria) · 2026Article
- Anti-Prion Systems in Saccharomyces cerevisiae.Journal of neurochemistry · 2025Review
- Innate immunity to prions: anti-prion systems turn a tsunami of prions into a slow drip.Current genetics · 2021Review
- Yeast and Fungal Prions.Cold Spring Harbor perspectives in biology · 2016Review
- Prions are affected by evolution at two levels.Cellular and molecular life sciences : CMLS · 2016Review
- Yeast and Fungal Prions: Amyloid-Handling Systems, Amyloid Structure, and Prion Biology.Advances in genetics · 2016Article
- Yeast prions: structure, biology, and prion-handling systems.Microbiology and molecular biology reviews : MMBR · 2015Review
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- Amyloid diseases of yeast: prions are proteins acting as genes.Essays in biochemistry · 2014Article
- The [URE3] prion in Candida.Eukaryotic cell · 2013Article
- Amyloids and yeast prion biology.Biochemistry · 2013Article
- Prions in yeast.Genetics · 2012Review
- Prion domain of yeast Ure2 protein adopts a completely disordered structure: a solid-support EPR study.PloS one · 2012Article
- Amyloid of the Candida albicans Ure2p prion domain is infectious and has an in-register parallel β-sheet structure.Biochemistry · 2011Article
- Prion diseases of yeast: amyloid structure and biology.Seminars in cell & developmental biology · 2011Review
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- Relationship between prion propensity and the rates of individual molecular steps of fibril assembly.The Journal of biological chemistry · 2011Article
- Ure2 is involved in nitrogen catabolite repression and salt tolerance via Ca2+ homeostasis and calcineurin activation in the yeast Hansenula polymorpha.The Journal of biological chemistry · 2010Article
- Genetic and epigenetic control of the efficiency and fidelity of cross-species prion transmission.Molecular microbiology · 2010Article
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5 authors.
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No grant is acknowledged in the PubMed record.
Abstract
The yeast inheritable [URE3] element corresponds to a prion form of the nitrogen catabolism regulator Ure2p. We have isolated several orthologous URE2 genes in different yeast species: Saccharomyces paradoxus, S. uvarum, Kluyveromyces lactis, Candida albicans, and Schizosaccharomyces pombe. We show here by in silico analysis that the GST-like functional domain and the prion domain of the Ure2 proteins have diverged separately, the functional domain being more conserved through the evolution. The more extreme situation is found in the two S. pombe genes, in which the prion domain is absent. The functional analysis demonstrates that all the homologous genes except for the two S. pombe genes are able to complement the URE2 gene deletion in a S. cerevisiae strain. We show that in the two most closely related yeast species to S. cerevisiae, i.e., S. paradoxus and S. uvarum, the prion domains of the proteins have retained the capability to induce [URE3] in a S. cerevisiae strain. However, only the S. uvarum full-length Ure2p is able to behave as a prion. We also show that the prion inactivation mechanisms can be cross-transmitted between the S. cerevisiae and S. uvarum prions.
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