ArticleMolecular biology of the cell2003
Irod/Ian5: an inhibitor of gamma-radiation- and okadaic acid-induced apoptosis.
Article in Molecular biology of the cell, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 60 citations in OpenAlex.
- Integrated weighted gene coexpression network analysis identifies Frizzled 2 (FZD2) as a key gene in invasive malignant pleomorphic adenoma.Journal of translational medicine · 2022Article
- The three as: Alternative splicing, alternative polyadenylation and their impact on apoptosis in immune function.Immunological reviews · 2021Review
- The GIMAP Family Proteins: An Incomplete Puzzle.Frontiers in immunology · 2021Review
- Article
- Alternative Polyadenylation in Human Diseases.Endocrinology and metabolism (Seoul, Korea) · 2017Review
- Functional and biochemical characterization of a T cell-associated anti-apoptotic protein, GIMAP6.The Journal of biological chemistry · 2017Article
- Cell Death Inducing Microbial Protein Phosphatase Inhibitors--Mechanisms of Action.Marine drugs · 2015Review
- Article
- Gimap and T cells: a matter of life or death.European journal of immunology · 2014Article
- Generation and characterisation of mice deficient in the multi-GTPase domain containing protein, GIMAP8.PloS one · 2014Article
- BB rat Gimap gene expression in sorted lymphoid T and B cells.Life sciences · 2011Article
- Critical role for Gimap5 in the survival of mouse hematopoietic stem and progenitor cells.The Journal of experimental medicine · 2011Article
- The apoptosis-inducing activity towards leukemia and lymphoma cells in a cyanobacterial culture collection is not associated with mouse bioassay toxicity.Journal of industrial microbiology & biotechnology · 2011Article
- GTP-dependent scaffold formation in the GTPase of Immunity Associated Protein family.Small GTPases · 2011Article
- Gimap3: A foot-in-the-door to tissue-specific regulation of mitochondrial DNA genetics.Small GTPases · 2011Article
- The autoimmunity-related GIMAP5 GTPase is a lysosome-associated protein.Self/nonself · 2010Article
- GIMAP Proteins in T-Lymphocytes.Journal of signal transduction · 2010Article
- Marine benthic diatoms contain compounds able to induce leukemia cell death and modulate blood platelet activity.Marine drugs · 2009Article
- Expression of GIMAP1, a GTPase of the immunity-associated protein family, is not up-regulated in malaria.Malaria journal · 2009Article
- CHOP mediates endoplasmic reticulum stress-induced apoptosis in Gimap5-deficient T cells.PloS one · 2009Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Protein phosphatase-directed toxins such as okadaic acid (OA) are general apoptosis inducers. We show that a protein (inhibitor of radiation- and OA-induced apoptosis, Irod/Ian5), belonging to the family of immune-associated nucleotide binding proteins, protected Jurkat T-cells against OA- and gamma-radiation-induced apoptosis. Unlike previously described antiapoptotic proteins Irod/Ian5 did not protect against anti-Fas, tumor necrosis factor-alpha, staurosporine, UV-light, or a number of chemotherapeutic drugs. Irod antagonized a calmodulin-dependent protein kinase II-dependent step upstream of activation of caspase 3. Irod has predicted GTP-binding, coiled-coil, and membrane binding domains. Irod localized to the centrosomal/Golgi/endoplasmic reticulum compartment. Deletion of either the C-terminal membrane binding domain or the N-terminal GTP-binding domain did not affect the antiapoptotic function of Irod, nor the centrosomal localization. The middle part of Irod, containing the coiled-coil domain, was therefore responsible for centrosomal anchoring and resistance toward death. Being widely expressed and able to protect also nonimmune cells, the function of Irod may not be limited to the immune system. The function and localization of Irod indicate that the centrosome and calmodulin-dependent protein kinase II may have important roles in apoptosis signaling.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.