ArticleMolecular biology of the cell2003
A monitor for bud emergence in the yeast morphogenesis checkpoint.
Article in Molecular biology of the cell, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed, 68 citations in OpenAlex.
- Article
- The mitotic exit network regulates the spatiotemporal activity of Cdc42 to maintain cell size.The Journal of cell biology · 2021Article
- Masters of asymmetry - lessons and perspectives from 50 years of septins.Molecular biology of the cell · 2020Review
- PRMT5 Cooperates with pICln to Function as a Master Epigenetic Activator of DNA Double-Strand Break Repair Genes.iScience · 2020Article
- Aggregate Filamentous Growth Responses in Yeast.mSphere · 2019Article
- Prolonged cyclin-dependent kinase inhibition results in septin perturbations during return to growth and mitosis.The Journal of cell biology · 2018Article
- A Synthetic Dosage Lethal Genetic Interaction Between CKS1B and PLK1 Is Conserved in Yeast and Human Cancer Cells.Genetics · 2016Article
- Kinetic partitioning during de novo septin filament assembly creates a critical G1 "window of opportunity" for mutant septin function.Cell cycle (Georgetown, Tex.) · 2016Article
- Sensing a bud in the yeast morphogenesis checkpoint: a role for Elm1.Molecular biology of the cell · 2016Article
- Regulation of Sphingolipid Biosynthesis by the Morphogenesis Checkpoint Kinase Swe1.The Journal of biological chemistry · 2016Article
- Septins and Generation of Asymmetries in Fungal Cells.Annual review of microbiology · 2015Review
- A lysine deacetylase Hos3 is targeted to the bud neck and involved in the spindle position checkpoint.Molecular biology of the cell · 2014Article
- Megadalton-node assembly by binding of Skb1 to the membrane anchor Slf1.Molecular biology of the cell · 2014Article
- Compartmentalized nodes control mitotic entry signaling in fission yeast.Molecular biology of the cell · 2013Article
- Feedback control of Swe1p degradation in the yeast morphogenesis checkpoint.Molecular biology of the cell · 2013Article
- The role of autophagy in genome stability through suppression of abnormal mitosis under starvation.PLoS genetics · 2013Article
- Article
- Roles of Hsl1p and Hsl7p in Swe1p degradation: beyond septin tethering.Eukaryotic cell · 2012Article
- RNA-dependent regulation of the cell wall stress response.Nucleic acids research · 2012Article
- Morphogenesis and the cell cycle.Genetics · 2012Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Cell cycle transitions are subject to regulation by both external signals and internal checkpoints that monitor satisfactory progression of key cell cycle events. In budding yeast, the morphogenesis checkpoint arrests the cell cycle in response to perturbations that affect the actin cytoskeleton and bud formation. Herein, we identify a step in this checkpoint pathway that seems to be directly responsive to bud emergence. Activation of the kinase Hsl1p is dependent upon its recruitment to a cortical domain organized by the septins, a family of conserved filament-forming proteins. Under conditions that delayed or blocked bud emergence, Hsl1p recruitment to the septin cortex still took place, but hyperphosphorylation of Hsl1p and recruitment of the Hsl1p-binding protein Hsl7p to the septin cortex only occurred after bud emergence. At this time, the septin cortex spread to form a collar between mother and bud, and Hsl1p and Hsl7p were restricted to the bud side of the septin collar. We discuss models for translating cellular geometry (in this case, the emergence of a bud) into biochemical signals regulating cell proliferation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.