ArticleMolecular biology of the cell2003
Hypoxia regulates assembly of cilia in suppressors of Tetrahymena lacking an intraflagellar transport subunit gene.
Article in Molecular biology of the cell, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 49 citations in OpenAlex.
- Review
- Ciliary and Non-Ciliary Roles of IFT88 in Development and Diseases.International journal of molecular sciences · 2025Review
- Demography and movement patterns of a freshwater ciliate: The influence of oxygen availability.Ecology and evolution · 2024Article
- HighAltitudeOmicsDB, an integrated resource for high-altitude associated genes and proteins, networks and semantic-similarities.Scientific reports · 2023Article
- Anterior-posterior pattern formation in ciliates.The Journal of eukaryotic microbiology · 2022Review
- Fluorescence imaging of beta cell primary cilia.Frontiers in endocrinology · 2022Article
- STORM imaging reveals the spatial arrangement of transition zone components and IFT particles at the ciliary base in Tetrahymena.Scientific reports · 2021Article
- The N-terminus of IFT46 mediates intraflagellar transport of outer arm dynein and its cargo-adaptor ODA16.Molecular biology of the cell · 2017Article
- The Central Apparatus of Cilia and Eukaryotic Flagella.Cold Spring Harbor perspectives in biology · 2017Review
- Structural and Functional Recovery of Sensory Cilia in C. elegans IFT Mutants upon Aging.PLoS genetics · 2016Article
- HIF Stabilization Weakens Primary Cilia.PloS one · 2016Article
- Assembly of IFT trains at the ciliary base depends on IFT74.Current biology : CB · 2015Article
- TCTEX1D2 mutations underlie Jeune asphyxiating thoracic dystrophy with impaired retrograde intraflagellar transport.Nature communications · 2015Article
- The CSC proteins FAP61 and FAP251 build the basal substructures of radial spoke 3 in cilia.Molecular biology of the cell · 2015Article
- Kinesin-13 regulates the quantity and quality of tubulin inside cilia.Molecular biology of the cell · 2015Article
- Total internal reflection fluorescence microscopy of intraflagellar transport in Tetrahymena thermophila.Methods in cell biology · 2015Article
- Intraflagellar transport gene expression associated with short cilia in smoking and COPD.PloS one · 2014Article
- CCTalpha and CCTdelta chaperonin subunits are essential and required for cilia assembly and maintenance in Tetrahymena.PloS one · 2010Article
- The paraflagellar rod of kinetoplastid parasites: from structure to components and function.International journal for parasitology · 2010Review
- DYF-1 Is required for assembly of the axoneme in Tetrahymena thermophila.Eukaryotic cell · 2009Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We cloned a Tetrahymena thermophila gene, IFT52, encoding a homolog of the Chlamydomonas intraflagellar transport protein, IFT52. Disruption of IFT52 led to loss of cilia and incomplete cytokinesis, a phenotype indistinguishable from that of mutants lacking kinesin-II, a known ciliary assembly transporter. The cytokinesis failures seem to result from lack of cell movement rather than from direct involvement of ciliary assembly pathway components in cytokinesis. Spontaneous partial suppressors of the IFT52 null mutants occurred, which assembled cilia at high cell density and resorbed cilia at low cell density. The stimulating effect of high cell density on cilia formation is based on the creation of pericellular hypoxia. Thus, at least under certain conditions, ciliary assembly is affected by an extracellular signal and the Ift52p function may be integrated into signaling pathways that regulate ciliogenesis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.