ArticleProceedings of the National Academy of Sciences of the United States of America2003
Homez, a homeobox leucine zipper gene specific to the vertebrate lineage.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 20 citations in OpenAlex.
- Downstream Target Analysis for miR-365 among Oral Squamous Cell Carcinomas Reveals Differential Associations with Chemoresistance.Life (Basel, Switzerland) · 2024Article
- Homeodomain protein HOMEZ is dispensable for male fertility in mice.Translational andrology and urology · 2022Article
- Homeodomain proteins: an update.Chromosoma · 2016Review
- Cis-eQTL analysis and functional validation of candidate susceptibility genes for high-grade serous ovarian cancer.Nature communications · 2015Article
- Aberrantly Expressed OTX Homeobox Genes Deregulate B-Cell Differentiation in Hodgkin Lymphoma.PloS one · 2015Article
- Identification of two novel mutations of the HOMEZ gene in Chinese patients with isolated ventricular septal defect.Genetic testing and molecular biomarkers · 2013Article
- Novel structural features in two ZHX homeodomains derived from a systematic study of single and multiple domains.BMC structural biology · 2010Article
- Article
- Replication of association between schizophrenia and ZNF804A in the Irish Case-Control Study of Schizophrenia sample.Molecular psychiatry · 2010Article
- Classification and nomenclature of all human homeobox genes.BMC biology · 2007Article
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Authors and funding
6 authors at 3 institutions in 1 country.
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Abstract
This work describes a vertebrate homeobox gene, designated Homez (homeodomain leucine zipper-encoding gene), that encodes a protein with an unusual structural organization. There are several regions within Homez, including three atypical homeodomains, two leucine zipper-like motifs, and an acidic domain. The gene is ubiquitously expressed in human and murine tissues, although the expression pattern is more restricted during mouse development. Genomic analysis revealed that human and mouse genes are located at 14q11.2 and 14C, respectively, and are composed of two exons. The zebrafish and pufferfish homologs share high similarity to mammalian sequences, particularly within the homeodomain sequences. Based on homology of homeodomains and on the similarity in overall protein structure, we delineate Homez and members of ZHX family of zinc finger homeodomain factors as a subset within the superfamily of homeobox-containing proteins. The type and composition of homeodomains in the Homez subfamily are vertebrate-specific. Phylogenetic analysis indicates that Homez lineage was separated from related genes >400 million years ago before separation of ray- and lobe-finned fishes. We apply a duplication-degeneration-complementation model to explain how this family of genes has evolved.
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