ArticleThe Journal of cell biology2003
Spatial and temporal changes in Bax subcellular localization during anoikis.
Article in The Journal of cell biology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed.
- Cell-Type-Specific Calibration of Mitochondrial Ubiquitination in Stem Cell Fate Decisions.Stem cell reviews and reports · 2026Review
- BAX activation in mouse retinal ganglion cells occurs in two temporally and mechanistically distinct steps.Molecular neurodegeneration · 2023Article
- BAX activation in mouse retinal ganglion cells occurs in two temporally and mechanistically distinct steps.Research square · 2023Article
- Regorafenib induces Bim-mediated intrinsic apoptosis by blocking AKT-mediated FOXO3a nuclear export.Cell death discovery · 2023Article
- Bak instead of Bax plays a key role in metformin-induced apoptosis s in HCT116 cells.Cell death discovery · 2021Article
- Stoichiometry and regulation network of Bcl-2 family complexes quantified by live-cell FRET assay.Cellular and molecular life sciences : CMLS · 2020Article
- Heat stress induces apoptosis through disruption of dynamic mitochondrial networks in dairy cow mammary epithelial cells.In vitro cellular & developmental biology. Animal · 2020Article
- Mitochondrial residence of the apoptosis inducer BAX is more important than BAX oligomerization in promoting membrane permeabilization.The Journal of biological chemistry · 2020Article
- Mechanisms of redox metabolism and cancer cell survival during extracellular matrix detachment.The Journal of biological chemistry · 2018Review
- Release of Cytochrome C from Bax Pores at the Mitochondrial Membrane.Scientific reports · 2017Article
- ERK-regulated αB-crystallin induction by matrix detachment inhibits anoikis and promotes lung metastasis in vivo.Oncogene · 2015Article
- Differential retrotranslocation of mitochondrial Bax and Bak.The EMBO journal · 2015Article
- Maintenance of Viability and Function of Rat Islets With the Use of ROCK Inhibitor Y-27632.Cell medicine · 2013Article
- Imperatorin sensitizes anoikis and inhibits anchorage-independent growth of lung cancer cells.Journal of natural medicines · 2013Article
- Bax exists in a dynamic equilibrium between the cytosol and mitochondria to control apoptotic priming.Molecular cell · 2013Article
- The C-terminal helix of Bcl-x(L) mediates Bax retrotranslocation from the mitochondria.Cell death and differentiation · 2013Article
- An integrin-ILK-microtubule network orients cell polarity and lumen formation in glandular epithelium.Nature cell biology · 2013Article
- Induction of heat shock protein 70 inhibits ischemic renal injury.Kidney international · 2011Article
- pH-sensitivity of YFP provides an intracellular indicator of programmed cell death.Plant methods · 2010Article
- BAX insertion, oligomerization, and outer membrane permeabilization in brain mitochondria: role of permeability transition and SH-redox regulation.Biochimica et biophysica acta · 2010Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Bax, a member of the Bcl-2 family, translocates to mitochondria during apoptosis, where it forms oligomers which are thought to release apoptogenic factors such as cytochrome c. Using anoikis as a model system, we have examined spatial and temporal changes in Bax distribution. Bax translocates to mitochondria within 15 min of detaching cells from extracellular matrix, but mitochondrial permeabilization does not occur for a number of hours. The formation of Bax oligomers and perimitochondrial clusters occurs concomitant with caspase activation and loss of mitochondrial membrane potential, before nuclear condensation. Cells can be rescued from apoptosis if they are replated onto extracellular matrix within an hour, whereas cells detached for longer could not. The loss of ability to rescue cells from anoikis occurs after Bax translocation, but before the formation of clusters and cytochrome c release. Our data suggest that Bax regulation occurs at several levels, with formation of clusters a late event, and with critical changes determining cell fate occurring earlier.
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