ReviewThe Journal of clinical investigation2003
Beta-agonists and asthma: too much of a good thing?
Review in The Journal of clinical investigation, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed.
- Effect of beta2-adrenergic receptor polymorphism on response to longacting beta2 agonist in asthma (LARGE trial): a genotype-stratified, randomised, placebo-controlled, crossover trial.Lancet (London, England) · 2009Trial
- The safety and effects of the beta-blocker, nadolol, in mild asthma: an open-label pilot study.Pulmonary pharmacology & therapeutics · 2008Trial
- beta-Adrenergic receptor polymorphisms and response to salmeterol.American journal of respiratory and critical care medicine · 2006Trial
- Effect of the Arg16Gly βAllergy · 2026Article
- Oxylipin Profiling of Airway Structural Cells Is Unique and Modified by Relevant Stimuli.Journal of proteome research · 2025Article
- Respiratory syncytial virus induces βScience signaling · 2021Article
- Effects of β-blockers on house dust mite-driven murine models pre- and post-development of an asthma phenotype.Pulmonary pharmacology & therapeutics · 2017Article
- Heat Shock-Related Protein 20 Peptide Decreases Human Airway Constriction Downstream of β2-Adrenergic Receptor.American journal of respiratory cell and molecular biology · 2016Article
- Defective Resensitization in Human Airway Smooth Muscle Cells Evokes β-Adrenergic Receptor Dysfunction in Severe Asthma.PloS one · 2015Article
- In vitro and in vivo pharmacological profile of PL-3994, a novel cyclic peptide (Hept-cyclo(Cys-His-Phe-d-Ala-Gly-Arg-d-Nle-Asp-Arg-Ile-Ser-Cys)-Tyr-[Arg mimetic]-NH(2)) natriuretic peptide receptor-A agonist that is resistant to neutral endopeptidase and acts as a bronchodilator.Pulmonary pharmacology & therapeutics · 2013Article
- β2-Adrenoceptor agonists are required for development of the asthma phenotype in a murine model.American journal of respiratory cell and molecular biology · 2013Article
- G-protein coupled receptor resensitization-appreciating the balancing act of receptor function.Current molecular pharmacology · 2012Article
- A novel EST-derived RNAi screen reveals a critical role for farnesyl diphosphate synthase in β2-adrenergic receptor internalization and down-regulation.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2012Article
- Article
- Regulation of β-adrenergic receptor function: an emphasis on receptor resensitization.Cell cycle (Georgetown, Tex.) · 2011Review
- Gastrin-releasing peptide blockade as a broad-spectrum anti-inflammatory therapy for asthma.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Beta2-adrenoceptor signaling is required for the development of an asthma phenotype in a murine model.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Differential desensitization of homozygous haplotypes of the beta2-adrenergic receptor in lymphocytes.American journal of respiratory and critical care medicine · 2005Article
- Long-acting beta 2-adrenoceptor agonists and exercise-induced asthma: lessons to guide us in the future.Paediatric drugs · 2004Review
Corrections and comments
- Comment on
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In an unusual paradox, asthmatics who are chronically treated with bronchodilating beta-agonists sometimes experience a worsening of their condition. A new study describes one possible mechanism and reveals a potential new therapeutic target in the treatment of asthma.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.