ArticleThe Journal of experimental medicine2003
Prostaglandin D2 reinforces Th2 type inflammatory responses of airways to low-dose antigen through bronchial expression of macrophage-derived chemokine.
Article in The Journal of experimental medicine, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed, 116 citations in OpenAlex.
- Oxylipin Profiling of Airway Structural Cells Is Unique and Modified by Relevant Stimuli.Journal of proteome research · 2025Article
- From thymus to tissues and tumors: A review of T-cell biology.The Journal of allergy and clinical immunology · 2023Review
- Effects of Avenanthramide on the Small Intestinal Damage through Hsp70-NF-κB Signaling in an Ovalbumin-Induced Food Allergy Model.International journal of molecular sciences · 2022Article
- Review
- Environmental allergens house dust mite-induced asthma is associated with ferroptosis in the lungs.Experimental and therapeutic medicine · 2021Article
- Leptin ElicitsFrontiers in endocrinology · 2020Article
- Prostaglandins in asthma and allergic diseases.Pharmacology & therapeutics · 2019Review
- Mast Cells and Their Progenitors in Allergic Asthma.Frontiers in immunology · 2019Review
- Unique Lipid Signatures of Extracellular Vesicles from the Airways of Asthmatics.Scientific reports · 2018Article
- Interferon Potentiates Toll-Like Receptor-Induced Prostaglandin DFrontiers in immunology · 2017Article
- CRTH2 antagonists in asthma: current perspectives.Clinical pharmacology : advances and applications · 2017Review
- Discovery of anti-inflammatory role of prostaglandin DThe Journal of veterinary medical science · 2016Review
- PGD2 deficiency exacerbates food antigen-induced mast cell hyperplasia.Nature communications · 2015Article
- Platelet-driven leukotriene C4-mediated airway inflammation in mice is aspirin-sensitive and depends on T prostanoid receptors.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- The role of prostaglandins in allergic lung inflammation and asthma.Expert review of respiratory medicine · 2015Review
- Key mediators in the immunopathogenesis of allergic asthma.International immunopharmacology · 2014Review
- Lipid mediators and allergic diseases.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2013Review
- Cyclooxygenase-2 in newborn hyperoxic lung injury.Free radical biology & medicine · 2013Article
- Anti-inflammatory role of PGD2 in acute lung inflammation and therapeutic application of its signal enhancement.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Mast cells contribute to double-stranded RNA-induced augmentation of airway eosinophilia in a murine model of asthma.Respiratory research · 2013Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
PGD2, a lipid mediator released from mast cells, is known to participate in allergic reactions. However, the mechanism by which PGD2 contributes to such reactions remains unclear. We established a novel experimental model of asthma that permitted direct assessment of the role of PGD2 in airway inflammation. Antigen-sensitized mice were exposed to aerosolized prostaglandin D2 (PGD2) 1 d before challenge with low-dose aerosolized antigen. Not only the numbers of eosinophils, lymphocytes, and macrophages but also the levels of IL-4 and IL-5 in bronchoalveolar lavage fluid were higher in PGD2-pretreated mice than in control mice. The expression of macrophage-derived chemokine (MDC), a chemoattractant for Th2 cells, was greater in PGD2-pretreated mice than in control. Injection of anti-MDC antibody into PGD2-pretreated mice markedly inhibited inflammatory cell infiltration as well as Th2 cyto-kine production after antigen challenge. These results indicate that PGD2 accelerates Th2 type inflammation by induction of MDC. Our results suggest that this mechanism may play a key role in the development of human asthma and that MDC might be a target molecule for therapeutic intervention.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.