ArticleBMC pediatrics2003
Interleukin-4 and 13 concentrations in infants at risk to develop Bronchopulmonary Dysplasia.
Article in BMC pediatrics, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.
- Association of Chorioamnionitis With Bronchopulmonary Dysplasia Among Preterm Infants: A Systematic Review, Meta-analysis, and Metaregression.JAMA network open · 2019Pooled it
- Can serum periostin predict bronchopulmonary dysplasia in premature infants?Pediatric research · 2022Article
- Association of immune cell recruitment and BPD development.Molecular and cellular pediatrics · 2022Review
- The BPD trio? Interaction of dysregulated PDGF, VEGF, and TGF signaling in neonatal chronic lung disease.Molecular and cellular pediatrics · 2017Review
- Establishing the entity of neonatal acute respiratory distress syndrome.Journal of thoracic disease · 2017Article
- Pro-inflammatory immune responses in leukocytes of premature infants exposed to maternal chorioamnionitis or funisitis.Pediatric research · 2017Article
- Pulmonary Biomarkers of Bronchopulmonary Dysplasia.Biomarker insights · 2008Article
- Pulmonary inflammation and bronchopulmonary dysplasia.Journal of perinatology : official journal of the California Perinatal Association · 2006Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAn exaggerated inflammatory response occurs in the first few days of life in infants who subsequently develop bronchopulmonary dysplasia (BPD). The increase of inflammatory cytokines in many disease processes is generally balanced by a rise in anti-inflammatory cytokines. Interleukin-4 (IL-4) and interleukin-13 (IL-13) have been shown to inhibit production of several inflammatory cytokines important in the development of BPD.
methodsWe sought to determine if a correlation exists between the presence or absence of IL-4 and IL-13 in tracheal aspirates (TA) during the first 3 weeks of life and the development of BPD in premature infants. Serial TAs were prospectively obtained from 36 very low birth weight infants and IL-4 and IL-13 concentrations were determined by ELISA.
resultsInfants who developed BPD (n = 19) were less mature (25.3 +/- 0.02 wks vs. 27.8 +/- 0.05 wks; p < 0.001), and had lower birth weights (739 +/- 27 g vs.1052 +/- 41 g; p < 0.001). IL-4 and IL-13 were detectable in only 27 of 132 and 9 of 132 samples assayed respectively. Furthermore, the levels detected for IL-4 and IL-13 were very low and did not correlate with the development of BPD.
conclusionsTA concentrations of IL-4 and IL-13 do not increase significantly during acute lung injury in premature infants.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.