ArticleEuropean journal of clinical pharmacology2003
Changes in drug treatment in the elderly between 1971 and 2000.
Article in European journal of clinical pharmacology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.
- The prevalence of medication-related adverse events in inpatients-a systematic review and meta-analysis.European journal of clinical pharmacology · 2017Pooled it
- Underrepresentation of elderly people in randomised controlled trials. The example of trials of 4 widely prescribed drugs.PloS one · 2012Article
- Increasing polypharmacy - an individual-based study of the Swedish population 2005-2008.BMC clinical pharmacology · 2010Article
- Potentially inappropriate medications in the elderly: the PRISCUS list.Deutsches Arzteblatt international · 2010Article
- Pharmacoeconomics and aging.Drugs & aging · 2009Review
- Pharmacologic management of the older woman undergoing surgery.Women's health (London, England) · 2009Review
- Patterns of drug use and factors associated with polypharmacy and excessive polypharmacy in elderly persons: results of the Kuopio 75+ study: a cross-sectional analysis.Drugs & aging · 2009Article
- The elderly--a challenge for appropriate drug treatment.European journal of clinical pharmacology · 2008Article
- The clinical implications of ageing for rational drug therapy.European journal of clinical pharmacology · 2008Review
- Adverse drug effects in elderly people -- a disparity between clinical examination and adverse effects self-reported by the patient.European journal of clinical pharmacology · 2007Article
- Eszopiclone for late-life insomnia.Clinical interventions in aging · 2007Review
- Evolution of medication use in Jerusalem elders: Results from the Jerusalem Longitudinal Study.Drugs & aging · 2007Article
- Article
- Self-reported drug utilization, health, and lifestyle factors among 70-74 year old community dwelling individuals in Western Norway. The Hordaland Health Study (HUSK).BMC public health · 2006Article
- Increasing use of medicines in elderly persons: a five-year follow-up of the Kuopio 75+Study.European journal of clinical pharmacology · 2006Article
- Drug use by the elderly in general practice: effects on upper gastrointestinal symptoms.European journal of clinical pharmacology · 2006Article
- Drug treatment modalities in psychiatric inpatient practice: a 20-year comparison.European archives of psychiatry and clinical neuroscience · 2005Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo investigate changes in drug treatment among elderly men and women over a 29-year period between 1971 and 2000.
methodsDrug consumption was investigated in five representative population samples of 70-year-olds born in 1901-1902 (n=973), 1906-1907 (n=1036), 1911-1912 (n=619), 1922 (n=449) and 1930 (n=506) and in three representative samples of 79- to 80-year-olds born in 1901-1902 (n=537), 1906-1907 (n=538) and 1915 (n=212).
resultsThe proportion of 70-year-olds who used drugs increased from 60% to 79% in men and from 76% to 88% in women from 1972 to 2000. Among 80-year-olds, 21% of the men and 11% of the women were without drug treatment in 1980, compared with 7% in 1995. The average number of drugs among 70-year-olds on treatment increased during the observation period from 2.8 to 3.5 in men and from 2.8 to 4.0 in women. At age 79-80 years, the mean number of drugs was 3.3 in men and 4.0 in women in 1980 and 4.0 in men and 4.7 in women in 1995. The most common drugs were cardiovascular drugs, analgesics and drugs for diseases in the central nervous system. The most pronounced changes in the consumption of specific drugs were found for anti-ulcerative drugs (increased), digitalis (decreased), diuretics (decreased in women), anti-thrombotic drugs (increased), calcium/vitamin D (increased), insulin (increased in men aged 70 years), analgesics (increased), levaxin (increased in women), anti-depressants (increased in women aged 70 years) and oestrogen in women (increased). The treatment patterns for cardiovascular diseases changed during the observation period and the use of calcium antagonists, angiotensin converting enzyme inhibitors, beta-blockers and lipid-lowering drugs increased.
conclusionThe proportion of the population with drug treatment at ages 70 years and 79-80 years increased as did the average number of drugs among treated subjects between 1971 and 2000. Important differences in the treatment patterns for different diseases were observed.
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