ArticleGenes & development2003
Identification of the C-signal, a contact-dependent morphogen coordinating multiple developmental responses in Myxococcus xanthus.
Article in Genes & development, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
55 citing papers in PubMed, 134 citations in OpenAlex.
- Milestones in the development ofJournal of bacteriology · 2025Review
- Article
- Article
- Mathematical modeling of mechanosensitive reversal control inFrontiers in microbiology · 2023Article
- Allopatric divergence of cooperators confers cheating resistance and limits effects of a defector mutation.BMC ecology and evolution · 2022Article
- Development versus predation: Transcriptomic changes during the lifecycle ofFrontiers in microbiology · 2022Article
- Cell density, alignment, and orientation correlate with C-signal-dependent gene expression duringProceedings of the National Academy of Sciences of the United States of America · 2021Article
- Microbiologically-Synthesized Nanoparticles and Their Role in Silencing the Biofilm Signaling Cascade.Frontiers in microbiology · 2021Review
- Transcriptome dynamics of theeLife · 2019Article
- A TonB-dependent transporter is required for secretion of protease PopC across the bacterial outer membrane.Nature communications · 2019Article
- Ultrasensitive Response of Developing Myxococcus xanthus to the Addition of Nutrient Medium Correlates with the Level of MrpC.Journal of bacteriology · 2018Article
- Fluorescence Live-cell Imaging of the Complete Vegetative Cell Cycle of the Slow-growing Social Bacterium Myxococcus xanthus.Journal of visualized experiments : JoVE · 2018Article
- Article
- Highly Signal-Responsive Gene Regulatory Network Governing Myxococcus Development.Trends in genetics : TIG · 2017Review
- Two-Component Signal Transduction Systems That Regulate the Temporal and Spatial Expression of Myxococcus xanthus Sporulation Genes.Journal of bacteriology · 2016Review
- Myxococcus CsgA, Drosophila Sniffer, and human HSD10 are cardiolipin phospholipases.Genes & development · 2015Article
- devI is an evolutionarily young negative regulator of Myxococcus xanthus development.Journal of bacteriology · 2015Article
- Combinatorial regulation of the dev operon by MrpC2 and FruA during Myxococcus xanthus development.Journal of bacteriology · 2015Article
- Exploiting Quorum Sensing Interfering Strategies in Gram-Negative Bacteria for the Enhancement of Environmental Applications.Frontiers in microbiology · 2015Review
- Transcription factor MrpC binds to promoter regions of hundreds of developmentally-regulated genes in Myxococcus xanthus.BMC genomics · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The regulated accumulation of the contact-dependent extracellular C-signal morphogen in the bacterium Myxococcus xanthus ensures the temporal and spatial coordination of multicellular morphogenesis and cellular differentiation during fruiting body formation. Synthesis of the C-signal depends on the csgA gene. The CsgA protein exists in two forms, the full-length 25-kD protein (p25), which is homologous to short-chain alcohol dehydrogenases, and a 17-kD protein (p17). The molecular nature of the C-signal has remained elusive. Here we show that p25 and p17 are associated with the outer membrane and that p17 copurifies with C-signal activity from M. xanthus cells. p17 corresponds to the C-terminal part of p25. A recombinant p17 protein, which lacks the N-terminal coenzyme binding pocket and which fails to bind NAD+ in vitro, has C-signal activity. These data provide evidence that p17 is the active species in C-signaling and that p17 does not act as a short-chain alcohol dehydrogenase to generate the C-signal. We further provide evidence that p17 is synthesized by N-terminal proteolytic processing of p25 by a serine protease. Compared to other bacterial signaling molecules, p17 is unusual with respect to size and cell-surface association. In these regards, C-signal is functionally analogous to eukaryotic signaling proteins.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.