ArticleGenes & development2003
Genetic interaction between Wnt/beta-catenin and BMP receptor signaling during formation of the AER and the dorsal-ventral axis in the limb.
Article in Genes & development, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
68 citing papers in PubMed, 137 citations in OpenAlex.
- Developmental and transcriptional programs that define the initiation of the forelimb.Development (Cambridge, England) · 2026Article
- A pivotal Wnt antagonist role promoting digit joint specification by constraining Wnt activity.Nature communications · 2026Article
- Developmental and transcriptional programs that define the initiation of the forelimb.bioRxiv : the preprint server for biology · 2025Article
- WNT signaling coordinately controls mouse limb bud outgrowth and establishment of the digit-interdigit pattern.Development (Cambridge, England) · 2025Article
- Article
- Wnt/β-catenin signaling components and mechanisms in bone formation, homeostasis, and disease.Bone research · 2024Review
- Article
- Thyroid Hormone Receptor α Controls the Hind Limb Metamorphosis by Regulating Cell Proliferation and Wnt Signaling Pathways inInternational journal of molecular sciences · 2022Article
- Recombinant Limb Assay asFrontiers in cell and developmental biology · 2022Article
- Wnt Signaling Coordinates the Expression of Limb Patterning Genes During Axolotl Forelimb Development and Regeneration.Frontiers in cell and developmental biology · 2022Article
- Hoxd13/Bmp2-mediated mechanism involved in zebrafish finfold design.Scientific reports · 2021Article
- Wnt/β-catenin signaling regulates adipose tissue lipogenesis and adipocyte-specific loss is rigorously defended by neighboring stromal-vascular cells.Molecular metabolism · 2020Article
- Wntless regulates lipogenic gene expression in adipocytes and protects against diet-induced metabolic dysfunction.Molecular metabolism · 2020Article
- Self-organized formation of developing appendages from murine pluripotent stem cells.Nature communications · 2019Article
- Characterization of cis-regulatory elements for Fgf10 expression in the chick embryo.Developmental dynamics : an official publication of the American Association of Anatomists · 2018Article
- John Saunders' ZPA, Sonic hedgehog and digit identity - How does it really all work?Developmental biology · 2017Review
- Ectoderm-mesoderm crosstalk in the embryonic limb: The role of fibroblast growth factor signaling.Developmental dynamics : an official publication of the American Association of Anatomists · 2017Review
- Armc5 deletion causes developmental defects and compromises T-cell immune responses.Nature communications · 2017Article
- How the embryo makes a limb: determination, polarity and identity.Journal of anatomy · 2015Review
- Anisotropic stress orients remodelling of mammalian limb bud ectoderm.Nature cell biology · 2015Article
8 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 5 institutions in 4 countries.
Funding
Abstract
By conditional gene ablation in mice, we found that beta-catenin, an essential downstream effector of canonical Wnt signaling, is a key regulator of formation of the apical ectodermal ridge (AER) and of the dorsal-ventral axis of the limbs. By generation of compound mutants, we also show that beta-catenin acts downstream of the BMP receptor IA in AER induction, but upstream or parallel in dorsal-ventral patterning. Thus, AER formation and dorsal-ventral patterning of limbs are tightly controlled by an intricate interplay between Wnt/beta-catenin and BMP receptor signaling.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.