ArticleAnnals of the rheumatic diseases2003
Factors associated with coronary artery calcification in young female patients with SLE.
Article in Annals of the rheumatic diseases, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 151 citations in OpenAlex.
- Complement Activation by Post-Translationally Modified Proteins: Links to Chronic Inflammation and Autoimmunity.Immunological reviews · 2026Review
- Rural-urban disparities in hospitalisation for myocardial infarction in systemic lupus erythematosus in the USA.Lupus science & medicine · 2025Article
- Coronary artery calcification progression and renal involvement in patients with systemic lupus erythematosus: a longitudinal cohort study.Rheumatology international · 2025Article
- Three-dimensional speckle tracking echocardiography for evaluation of ventricular function in patients with systemic lupus erythematosus: relationship between duration of lupus erythematosus and left ventricular dysfunction by using global longitudinal strain.The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology · 2024Article
- New insight of complement system in the process of vascular calcification.Journal of cellular and molecular medicine · 2023Review
- Cardiovascular disease in systemic lupus erythematosus.Rheumatology and immunology research · 2021Review
- Biomarkers associating endothelial Dysregulation in pediatric-onset systemic lupus erythematous.Pediatric rheumatology online journal · 2019Article
- Inflammatory, Serological and Vascular Determinants of Cardiovascular Disease in Systemic Lupus Erythematosus Patients.International journal of molecular sciences · 2019Article
- Cardiac Manifestations in Systemic Lupus Erythematosus: Clinical Correlates of Subclinical Echocardiographic Features.BioMed research international · 2019Article
- Progression of subclinical and clinical cardiovascular disease in a UK SLE cohort: the role of classic and SLE-related factors.Lupus science & medicine · 2018Article
- Cardiovascular Comorbidity in Inflammatory Rheumatological Conditions.Deutsches Arzteblatt international · 2017Review
- Article
- Cardiovascular Events in Systemic Lupus Erythematosus: A Nationwide Study in Spain From the RELESSER Registry.Medicine · 2015Article
- Alpha-chlorofatty Acid and coronary artery or aorta calcium scores in women with systemic lupus erythematosus. A pilot study.The Journal of rheumatology · 2014Article
- Pathogenesis and treatment of atherosclerosis in lupus.Rheumatic diseases clinics of North America · 2014Review
- Complement protein C3 and coronary artery calcium in middle-aged women with polycystic ovary syndrome and controls.Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology · 2014Article
- Atherosclerotic plaques occur in absence of intima-media thickening in both systemic sclerosis and systemic lupus erythematosus: a duplexsonography study of carotid and femoral arteries and follow-up for cardiovascular events.Arthritis research & therapy · 2014Article
- Aberrant regulation of the integrin very late antigen-4 in systemic lupus erythematosus.Lupus · 2013Article
- Semiquantified noncalcified coronary plaque in systemic lupus erythematosus.The Journal of rheumatology · 2012Article
- Frequency of established cardiovascular disease and its risk factors in Chinese patients with systemic lupus erythematosus.Clinical rheumatology · 2012Article
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWith improved survival rates of patients with systemic lupus erythematosus (SLE), damage such as accelerated atherosclerosis gains increasing importance.
objectiveTo identify the prevalence of coronary artery calcifications (CAC) in asymptomatic patients.
methodsElectron beam tomography (EBT) was performed in 75 female patients with SLE aged <50. The results were correlated with traditional and SLE related factors associated with CAC. 49 women with symptomatic coronary heart disease (CHD) and 279 women without CHD were also analysed.
resultsOverall, 21/75 (28%) patients had CAC. Low HDL cholesterol levels <1.40 mmol/l (p=0.03, OR=1.8, 67% v 39%) and cigarette smoking (p=0.01, OR=5.7, 76% v 44%) were identified as factors associated with CAC. Hypertension and high cholesterol were more common in women with CHD (p<0.01) than in those without CHD. SLE related factors were proteinuria (1331 v 465 mg/day, p=0.02), impaired renal function (p=0.02, OR=2.6, 26% v 6%), and high C3 levels (p=0.04, OR=1.8, 65% v 38%). High C3 levels were also more common in symptomatic CHD (p=0.02). The prevalence of Sm antibodies was lower in patients with CAC (15% v 42%, p=0.03). In a multivariate analysis, cigarette smoking, reduced renal function, high C3, and a cumulative steroid dose above 30 g were the most important CAC associated factors in the lupus cohort.
conclusionA subgroup of patients with SLE with CAC without any clinical symptoms of CHD was identified by EBT. Therefore, EBT is useful for assessing asymptomatic atherosclerosis in this group.
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