ReviewAnnals of the rheumatic diseases2003
Normal intestinal microbiota in the aetiopathogenesis of rheumatoid arthritis.
Review in Annals of the rheumatic diseases, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed, 86 citations in OpenAlex.
- Oral and Intestinal Bacterial Substances Associated with Disease Activities in Patients with Rheumatoid Arthritis: A Cross-Sectional Clinical Study.Journal of immunology research · 2022Trial
- Investigating the causal relationship between the gut microbiome and rheumatoid arthritis: mediating effects of immune cells.Journal of translational medicine · 2025Article
- Dysbiotic Oral and Gut Viromes in Untreated and Treated Rheumatoid Arthritis Patients.Microbiology spectrum · 2022Article
- The Use of Gut Microbial Modulation Strategies as Interventional Strategies for Ageing.Microorganisms · 2022Review
- Effects of intestinal microbes on rheumatic diseases: A bibliometric analysis.Frontiers in microbiology · 2022Article
- Article
- Synovial tissue transcriptomes of long-standing rheumatoid arthritis are dominated by activated macrophages that reflect microbial stimulation.Scientific reports · 2020Article
- Modulation of autoimmune arthritis by environmental 'hygiene' and commensal microbiota.Cellular immunology · 2019Review
- Review
- Review
- Contribution of bacterial pathogens to evoking serological disease markers and aggravating disease activity in rheumatoid arthritis.PloS one · 2018Article
- Transplanted human fecal microbiota enhanced Guillain Barré syndrome autoantibody responses after Campylobacter jejuni infection in C57BL/6 mice.Microbiome · 2017Article
- Inflammatory 'double hit' model of temporomandibular joint disorder with elevated CCL2, CXCL9, CXCL10, RANTES and behavioural hypersensitivity in TNFR1/R2-/- mice.European journal of pain (London, England) · 2017Article
- Managing Rheumatoid Arthritis with Dietary Interventions.Frontiers in nutrition · 2017Review
- Differential fecal microbiota are retained in broiler chicken lines divergently selected for fatness traits.Scientific reports · 2016Article
- Molecular Insight into Gut Microbiota and Rheumatoid Arthritis.International journal of molecular sciences · 2016Review
- Comparative Analysis of Gut Microbiota of Native Tibetan and Han Populations Living at Different Altitudes.PloS one · 2016Article
- Human Microbiome: When a Friend Becomes an Enemy.Archivum immunologiae et therapiae experimentalis · 2015Review
- Ranking the impact of human health disorders on gut metabolism: systemic lupus erythematosus and obesity as study cases.Scientific reports · 2015Article
- Fecal Microbiota Transplantation: A Review of Emerging Indications Beyond Relapsing Clostridium difficile Toxin Colitis.Gastroenterology & hepatology · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A series of observations have led to the hypothesis that normal intestinal microbiota in patients with rheumatoid arthritis may harbour, for genetic reasons, bacteria with cell walls capable of inducing arthritis. Differences occur between bacterial species, and even between strains of a single species, because some cell walls induce experimental chronic arthritis, whereas some others induce only a transient acute arthritis or no arthritis at all. In susceptible subjects, with continuous seeding of bacterial products from the gut, the synovial inflammation is followed by erosion, exposition of cartilage antigens, and self perpetuating chronic arthritis.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.