ReviewJournal of psychiatry & neuroscience : JPN2003
The role of GABAA receptors in mediating the effects of alcohol in the central nervous system.
Review in Journal of psychiatry & neuroscience : JPN, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 126 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Temporally-Resolved Electrophysiology of Acamprosate Treatment of Alcohol Use Disorder
Frontal E/I Balance Mediation of tACS Effects on Behavioral Flexibility
Who cites it
126 citing papers in PubMed, 3 syntheses or guidelines pooled it, 302 citations in OpenAlex.
- Effects of Alcohol on EEG Activity: A Systematic Review Focused on Sex-Related Differences in Youth.Current neuropharmacology · 2025Pooled it
- Age-related differences in the effect of chronic alcohol on cognition and the brain: a systematic review.Translational psychiatry · 2022Pooled it
- Association of gamma-aminobutyric acid A receptor α2 gene (GABRA2) with alcohol use disorder.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2014Pooled it
- Cognitive effects, pharmacokinetics, and safety of zuranolone administered alone or with alprazolam or ethanol in healthy adults in a phase 1 trial.Journal of psychopharmacology (Oxford, England) · 2024Trial
- Neuroendocrine response to GABA-B receptor agonism in alcohol-dependent individuals: Results from a combined outpatient and human laboratory experiment.Neuropharmacology · 2018Trial
- Subjective effects and changes in steroid hormone concentrations in humans following acute consumption of alcohol.Psychopharmacology · 2006Trial
- Reversible alterations of brain acetate metabolism associated with alcohol consumption.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Can Post-Mortem Cartilage Reliably Preserve Ethanol? A Time-Course Comparison with Blood and Urine.Toxics · 2026Article
- Silymarin Reverses Seizure-Precipitating Effects of Alcohol and Associated Psychiatric Comorbidities, and Neurotoxicity in Pentylenetetrazol Pre-Kindled Mice.Neurotoxicity research · 2026Article
- Dopamine D2 and GABA(A) Receptors Differentially Regulate Ethanol-Induced Aversion and Reward Through Corticolimbic Circuits.International journal of molecular sciences · 2026Article
- Sex differences in nucleus accumbens circuitry engaged with binge-like ethanol drinking.Psychopharmacology · 2026Article
- Review
- Sex differences in blackout: evidence of a relationship between disorders of arousal during sleep and alcohol-related blackout in females.Frontiers in psychology · 2026Review
- Chronic Alcoholism and Propofol Demand: The Impact of Alcohol Tolerance in Painless Gastrointestinal Endoscopy.JGH open : an open access journal of gastroenterology and hepatology · 2025Article
- Risk factors for morphine-associated sedation in intravenous patient-controlled analgesia for postoperative pain.BMC anesthesiology · 2025Article
- AlteredbioRxiv : the preprint server for biology · 2025Article
- N6-methyladenosine RNA methylation is a novel epitranscriptomic regulator of excessive alcohol drinking and vulnerability to relapse.bioRxiv : the preprint server for biology · 2025Article
- Article
- Exploring the Role of Oral Microbiota in the Pathophysiology and Treatment of Bruxism.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025Review
- Cerebellar Micro Complex Model Using Histologic Boolean Mapping Simulates Adaptive Motor Control.Neuroinformatics · 2025Article
66 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ethanol is a chemically simple compound that produces many well-known effects in humans. The prevailing idea for many years was that ethanol and other alcohols exerted their effects on the central nervous system (CNS) by non-selectively disrupting the lipid bilayers of neurons. However, in recent years, there has been an accumulation of evidence pointing to the importance of ligand-gated ion channels (LGICs) in mediating the effects of ethanol. Of these LGICs, gamma-aminobutyric acid type A (GABAA) receptors appear to occupy a central role in mediating the effects of ethanol in the CNS. GABA is the primary inhibitory neurotransmitter in the mammalian CNS, and activation of GABAA receptors by GABA tends to decrease neuronal excitability. This article reviews several aspects of GABAA receptor and ethanol interactions, including the evidence for short- and long-term modulation of GABAA receptors by ethanol and evidence for a GABAA receptor-related genetic component of alcoholism.
Indexed as
Identifiers
12921221PMC165791W2131858981What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.