ArticleDevelopmental cell2003
Nuclear translocation of LIM kinase mediates Rho-Rho kinase regulation of cyclin D1 expression.
Article in Developmental cell, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 56 citations in OpenAlex.
- Topical application ofPharmaceutical biology · 2019Article
- Cell cycle, cytoskeleton dynamics and beyond: the many functions of cyclins and CDK inhibitors.Cell cycle (Georgetown, Tex.) · 2015Review
- Active RHOA favors retention of human hematopoietic stem/progenitor cells in their niche.Journal of biomedical science · 2013Article
- The transience of transient overexpression.Nature methods · 2013Article
- The elements of human cyclin D1 promoter and regulation involved.Clinical epigenetics · 2011Article
- A structure filter for the Eukaryotic Linear Motif Resource.BMC bioinformatics · 2009Article
- Downregulation of LIM kinase 1 suppresses ocular inflammation and fibrosis.Molecular vision · 2008Article
- LIM kinases: function, regulation and association with human disease.Journal of molecular medicine (Berlin, Germany) · 2007Review
- Shape change controls supporting cell proliferation in lesioned mammalian balance epithelium.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
- Cell cycle regulation by the Wee1 inhibitor PD0166285, pyrido [2,3-d] pyimidine, in the B16 mouse melanoma cell line.BMC cancer · 2006Article
- The Rho GTPase effector ROCK regulates cyclin A, cyclin D1, and p27Kip1 levels by distinct mechanisms.Molecular and cellular biology · 2006Article
- Cyclin D1 regulates cellular migration through the inhibition of thrombospondin 1 and ROCK signaling.Molecular and cellular biology · 2006Article
- The activity status of cofilin is directly related to invasion, intravasation, and metastasis of mammary tumors.The Journal of cell biology · 2006Article
- Role of LIM kinases in normal and psoriatic human epidermis.Molecular biology of the cell · 2006Article
- Rho GTPase-dependent signaling is required for macrophage migration inhibitory factor-mediated expression of cyclin D1.The Journal of biological chemistry · 2005Article
- Actin-depolymerizing factor and cofilin-1 play overlapping roles in promoting rapid F-actin depolymerization in mammalian nonmuscle cells.Molecular biology of the cell · 2005Article
Corrections and comments
- Retraction · 2006-05-01Concerns/Issues about Data · Error in Image · Unreliable Image ·
- Commented on by
- Retracted
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
We previously reported that the Rho-Rho kinase pathway controls cyclin D1 expression by preventing its early G1 phase induction in response to Rac and/or Cdc42, thus increasing its dependence on ERK signaling and actin stress fiber formation. We now show that the Rho kinase effector LIM kinase is responsible for this effect. Surprisingly, inhibition of Rac-dependent cyclin D1 expression by LIM kinase is independent of both cofilin phosphorylation and actin polymerization. Instead, specific mutation of its nuclear localization and export sequences showed that LIM kinase acts in the nucleus to suppress Rac/Cdc42-dependent cyclin D1 expression. Our results therefore describe an unexpected role for LIM kinase that requires nuclear translocation. The effect of nuclear LIM kinase on cyclin D1 expression ultimately regulates the duration of G1 phase and the degree to which G1 phase progression depends on actin stress fiber formation and imposition of cellular tension.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.