Trial reportBritish journal of clinical pharmacology2003
Tacrolimus dose requirement in renal transplant recipients is significantly higher when used in combination with corticosteroids.
Trial report in British journal of clinical pharmacology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 80 citations in OpenAlex.
- Steroid avoidance or withdrawal for kidney transplant recipients.The Cochrane database of systematic reviews · 2016Pooled it
- Interleukin 2 receptor antagonists for kidney transplant recipients.The Cochrane database of systematic reviews · 2010Pooled it
- Tacrolimus Exposure is Associated with Acute Rejection in the Early Phase After Kidney Transplantation: A Joint Modeling Approach.Therapeutic drug monitoring · 2025Trial
- A Review of Population Pharmacokinetic Models and Dosing Algorithms Assessing the Influence of CYP3A5 Genotype and Other Clinical Covariates on Tacrolimus Pharmacokinetics.Clinical pharmacokinetics · 2026Review
- Steroid-tacrolimus drug-drug interaction and the effect of CYP3A genotypes.British journal of clinical pharmacology · 2024Article
- The Clinical Manifestation of Immunosuppressive Therapy as a Tool to Improve Immune Monitoring in Renal Transplant Recipients.Kidney & blood pressure research · 2023Article
- Influence ofInternational journal of molecular sciences · 2020Article
- The Clinical Impact of the CFrontiers in pharmacology · 2020Review
- Monitoring Tacrolimus Trough Concentrations During the First Year After Kidney Transplantation: A National Retrospective Cohort Study.Frontiers in pharmacology · 2020Article
- Interventions for preventing bone disease in kidney transplant recipients.The Cochrane database of systematic reviews · 2019Review
- A Population Pharmacokinetic Model to Predict the Individual Starting Dose of Tacrolimus Following Pediatric Renal Transplantation.Clinical pharmacokinetics · 2018Article
- The Effect of Weight and CYP3A5 Genotype on the Population Pharmacokinetics of Tacrolimus in Stable Paediatric Renal Transplant Recipients.Clinical pharmacokinetics · 2016Article
- The influence of comedication on tacrolimus blood concentration in patients subjected to kidney transplantation: a retrospective study.European journal of drug metabolism and pharmacokinetics · 2014Article
- Clinical pharmacokinetics and pharmacodynamics of prednisolone and prednisone in solid organ transplantation.Clinical pharmacokinetics · 2012Review
- The interactions of age, sex, body mass index, genetics, and steroid weight-based doses on tacrolimus dosing requirement after adult kidney transplantation.European journal of clinical pharmacology · 2012Article
- Novel polymorphisms associated with tacrolimus trough concentrations: results from a multicenter kidney transplant consortium.Transplantation · 2011Article
- Evaluation of limited sampling methods for estimation of tacrolimus exposure in adult kidney transplant recipients.British journal of clinical pharmacology · 2011Article
- Pharmacokinetics of tacrolimus in stable paediatric renal transplant recipients.Pediatric nephrology (Berlin, Germany) · 2010Article
- Immunotherapy in elderly transplant recipients: a guide to clinically significant drug interactions.Drugs & aging · 2009Review
- Functional implications of genetic polymorphisms in the multidrug resistance gene MDR1 (ABCB1).Pharmaceutical research · 2004Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsTo evaluate the effect of corticosteroids on tacrolimus pharmacokinetics.
methodsIn a randomized trial, kidney transplant recipients were treated with tacrolimus and mycophenolate mofetil with either daclizumab (n = 31) or 3 months of prednisone (n = 34). Tacrolimus dose-adjusted predose concentrations (C0) at month 1-6 were compared between both groups and within the corticosteroid group before and after prednisone withdrawal.
resultsAt month 1 the tacrolimus dose-adjusted C0 in the corticosteroid group was 83 +/- 8 vs 119 +/- 17 ng ml-1 mg-1 kg-1 in the daclizumab group. The tacrolimus dose-adjusted C0 within the corticosteroid group at month 1 and 2 was 42% and 29% lower compared with month 4 (P < 0.001).
conclusionsA higher tacrolimus dose is required to reach target concentrations when used in combination with corticosteroids.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.