Trial reportWorld journal of gastroenterology2003
Intestinal permeability in patients after surgical trauma and effect of enteral nutrition versus parenteral nutrition.
Trial report in World journal of gastroenterology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Enteral and parenteral nutrition in cancer patients, a comparison of complication rates: an updated systematic review and (cumulative) meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2020Pooled it
- Short-term evaluation of immune levels and nutritional values of EN versus PN in gastric cancer: a systematic review and a meta-analysis.World journal of surgical oncology · 2019Pooled it
- Pooled it
- Treatment of upper gastrointestinal fistula and leakage with personal stage nutrition support.World journal of gastroenterology · 2008Trial
- EARLY REFEEDING AFTER COLORECTAL CANCER SURGERY REDUCES COMPLICATIONS AND LENGTH OF HOSPITAL STAY.Arquivos brasileiros de cirurgia digestiva : ABCD = Brazilian archives of digestive surgery · 2025Article
- Article
- Zwitterionic micelles efficiently deliver oral insulin without opening tight junctions.Nature nanotechnology · 2020Article
- Endoscopic Nasoenteral Feeding Tube Fixation with Hemoclip Reduces Tube Dislodgement.Digestive diseases and sciences · 2020Article
- The Effects of Early Post-Operative Soluble Dietary Fiber Enteral Nutrition for Colon Cancer.Nutrients · 2016Article
- Catecholamines, steroids and immune alterations in ischemic stroke and other acute diseases.Aging and disease · 2014Review
- Timing of (supplemental) parenteral nutrition in critically ill patients: a systematic review.Annals of intensive care · 2014Review
- Nutrition support in surgical patients with colorectal cancer.World journal of gastroenterology · 2011Article
- Small intestinal permeability and serum folate and cobalamin absorption after surgical construction of permanent jejunal fistulas in laboratory beagle dogs.Comparative medicine · 2010Article
- Enteral and parenteral nutrition distinctively modulate intestinal permeability and T cell function in vitro.European journal of nutrition · 2009Article
- Nutritional support in gastrointestinal surgery: an overview.The Indian journal of surgery · 2008Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo study the intestinal permeability (IP) following stress of abdominal operation and the different effects on IP of enteral nutrition (EN) and parenteral nutrition (PN).
methodsForty patients undergoing abdominal surgery were randomized into EN group and PN group. Each group received nutritional support of the same nitrogen and calorie from postoperative day (POD) 3 to POD 11. On the day before operation (POD-1), POD 7 and POD 12, 10 g of lactulose and 5 g of mannitol were given orally, and urine was collected for 6 hours. Urine excretion ratios of lactulose and mannitol (L/M) were measured.
resultsL/M ratios of EN group on POD-1, POD 7 and POD 12 were 0.026+/-0.017, 0.059+/-0.026, 0.027+/-0.017, respectively, and those of PN group were 0.025+/-0.013, 0.080+/-0.032, 0.047+/-0.021, respectively. Patients of both groups had elevated L/M ratios on POD 7 vs. POD-1. However the ratio returned toward control level in EN group by POD 12. In contrast, PN group still had elevated L/M ratios on POD 12.
conclusionL/M ratio increases for a period of time after surgical trauma and the loss of gut mucosal integrity can be reversed by substitution of enteral nutrition.
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