ArticleWorld journal of gastroenterology2003
cagA and vacA genotype of Helicobacter pylori associated with gastric diseases in Xi'an area.
Article in World journal of gastroenterology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- Association between vacA genotypes and the risk of duodenal ulcer: a meta-analysis.Molecular biology reports · 2014Pooled it
- Review
- Immunohistochemistry and molecular detection of Helicobacter pylori infection and their virulent genes in gastric biopsies.Scientific reports · 2026Article
- Review
- Correlation analysis of gastric mucosal lesions withAnnals of translational medicine · 2022Article
- Expression analysis of miRNA-155 level inIranian journal of microbiology · 2022Article
- Prevalence of Helicobacter pylori virulence genotypes among children in Eastern Turkey.World journal of gastroenterology · 2013Article
- Diversity of Helicobacter pylori genotypes in Iranian patients with different gastroduodenal disorders.World journal of gastroenterology · 2013Article
- Prevalence of Helicobacter pylori vacA, cagA and iceA genotypes and correlation with clinical outcome.Experimental and therapeutic medicine · 2012Article
- Molecular analysis of Helicobacter pylori virulent-associated genes in hepatobiliary patients.HPB : the official journal of the International Hepato Pancreato Biliary Association · 2012Article
- Prevalence of genotypes in Helicobacter pyloriisolates from patients in eastern Turkey and the association of these genotypes with clinical outcome.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2012Article
- cagA and vacA status and influence of Helicobacter pylori infection on serum oxidative DNA damage in Iranian patients with peptic ulcer disease.Irish journal of medical science · 2011Article
- Helicobacter pylori virulence factors in duodenal ulceration: A primary cause or a secondary infection causing chronicity.World journal of gastroenterology · 2006Article
- A new subtype of 3' region of cagA gene in Helicobacter pylori strains isolated from Zhejiang Province in China.World journal of gastroenterology · 2004Article
- Helicobacter pylori cagA, iceA and vacA genotypes in patients with gastric cancer in Taiwan.World journal of gastroenterology · 2004Article
- Antigen epitope of Helicobacter pylori vacuolating cytotoxin A.World journal of gastroenterology · 2004Article
- Helicobacter pylori: current status and future prospects.Science progress · 2004Review
Corrections and comments
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Authors and funding
7 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo establish stock of clinical Helicobacter pylori (H. pylori) isolates, to perform cagA and vacA typing of these isolates, to evaluate the relationship between genotypes of cagA and vacA and upper gastrointestinal diseases and to assess the association of vacA genotypes with presence of the pathogenicity marker-cagA.
methodsClinical H.pylori strains were isolated from the antrum of 259 patients in Clumbia agar. The isolated H.pylori strains were identified by histology, and16SrRNA PCR. CagA genotypes were detected by colony hybridization, the probe was derived from the cloned plasmid PcagA, and digested by EcoRI-HindIII and the isolated PcagA DNA fragment was radioactively labelled by the random priming method. vacA genes types (s,m)and subtypes (s1a, s1b, s2) were typed by PCR. Vacuolating toxin was detected with neutral red absorb test. The results were treated statistically by chi(2) test, t test, and rank sum test.
resultsA total of 192 clinical H.pylori strains were isolated and the stock of Helicobacter pylori was established. The total positive rate of cagA was 87 % in all gastric diseases, and 95 % in gastric cancer group. There was a difference between gastric cancer group and the other groups (P<0.05) except duodenal ulcer group. The expression of type s1 of vacA was more than type s2 (P<0.05), and, the expression of type m1 was equal to type m2. In gastric cancer group, there was a difference between s1a and s1b (P<0.05), and s1a was more than s1b. Vacuolating toxins were more in Xi'an area isolates.
conclusionThe cagA(+) vacA type s1 clinical isolates are more in Xi'an area, but this can not serve as an index to predict gastric cancer.
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