ArticleWorld journal of gastroenterology2003
Refinement of heterozygosity loss on chromosome 5p15 in sporadic colorectal cancer.
Article in World journal of gastroenterology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10 citing papers in PubMed, 22 citations in OpenAlex.
- Epigenetic Inactivation of the Tumor SuppressorCancers · 2020Article
- The aryl hydrocarbon receptor repressor - More than a simple feedback inhibitor of AhR signaling: Clues for its role in inflammation and cancer.Current opinion in toxicology · 2017Article
- Copy number variation in archival melanoma biopsies versus benign melanocytic lesions.Cancer biomarkers : section A of Disease markers · 2016Article
- Silencing NKD2 by promoter region hypermethylation promotes gastric cancer invasion and metastasis by up-regulating SOX18 in human gastric cancer.Oncotarget · 2015Article
- Tumor suppress genes screening analysis on 4q in sporadic colorectal carcinoma.World journal of gastroenterology · 2008Article
- Refined mapping of loss of heterozygosity on 1q31.1-32.1 in sporadic colorectal carcinoma.World journal of gastroenterology · 2008Article
- The aryl hydrocarbon receptor repressor is a putative tumor suppressor gene in multiple human cancers.The Journal of clinical investigation · 2008Article
- Are there tumor suppressor genes on chromosome 4p in sporadic colorectal carcinoma?World journal of gastroenterology · 2008Article
- Loss of heterozygosity on chromosome 1 in sporadic colorectal carcinoma.World journal of gastroenterology · 2004Article
- Expression analysis of aryl hydrocarbon receptor repressor (AHRR) gene in gallbladder cancer.Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology AssociationArticle
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Authors and funding
5 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
aimTo refine the loss of heterozygosity on chromosome 5p15 and to identify the new tumor suppressor gene (s) in colorectal tumorigenesis.
methodsSixteen polymorphic microsatellite markers were analyzed on chromosome 5 and another 6 markers were applied on chromosome 5p15 in 83 cases of colorectal and normal DNA by PCR. PCR products were electrophoresed on an ABI 377 DNA sequencer. Genescan 3.1 and Genotype 2.1 software were used for LOH scanning and analysis.
resultsWe observed 2 distinct regions of frequent allelic deletions on Chromosome 5, at D5S416 on 5p15 and D5S428-D5S410 on 5q. Another 6 polymorphric microsatellite markers were applied to 5p15 and the minimal region of frequent loss of heterozygosity was established on 5p15 spanning the D5S416 locus.
conclusionThrough our detailed deletion mapping studies, we have found a critical and precise location of 5p deletions, 5p15.2-5p15.3, which must contain one or more unknown tumor suppressor gene (s) of colorectal cancer.
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