ReviewWorld journal of gastroenterology2003
RNA interference: antiviral weapon and beyond.
Review in World journal of gastroenterology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 44 citations in OpenAlex.
- Life stage-dependent RNA interference in the tropical rock lobsterMarine life science & technology · 2026Article
- A determination of pan-pathogen antimicrobials?Medicine in drug discovery · 2022Review
- Review
- Bioenergetics and gene silencing approaches for unraveling nucleotide recognition by the human EIF2C2/Ago2 PAZ domain.PloS one · 2014Article
- RNAi-mediated double gene knockdown and gustatory perception measurement in honey bees (Apis mellifera).Journal of visualized experiments : JoVE · 2013Article
- RNAi: antiviral therapy against dengue virus.Asian Pacific journal of tropical biomedicine · 2013Review
- Inhibition of monkeypox virus replication by RNA interference.Virology journal · 2009Article
- RNA interference-mediated silencing of the respiratory syncytial virus nucleocapsid defines a potent antiviral strategy.Antimicrobial agents and chemotherapy · 2009Article
- RNA interference: from gene silencing to gene-specific therapeutics.Pharmacology & therapeutics · 2005Review
- A small interfering RNA targeting coxsackievirus B3 protects permissive HeLa cells from viral challenge.Journal of virology · 2005Article
- Molecular strategies to inhibit HIV-1 replication.Retrovirology · 2005Review
- siRNA-mediated inhibition of HBV replication and expression.World journal of gastroenterology · 2004Article
- Polymerase synthesis and potential interference of a small-interfering RNA targeting hPim-2.World journal of gastroenterology · 2004Article
- Effects of length and location on the cellular response to double-stranded RNA.Microbiology and molecular biology reviews : MMBR · 2004Review
- RNA interference directed against Poly(ADP-Ribose) polymerase 1 efficiently suppresses human immunodeficiency virus type 1 replication in human cells.Journal of virology · 2004Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
RNA interference (RNAi) is a remarkable type of gene regulation based on sequence-specific targeting and degradation of RNA. The term encompasses related pathways found in a broad range of eukaryotic organisms, including fungi, plants, and animals. RNA interference is part of a sophisticated network of interconnected pathways for cellular defense, RNA surveillance, and development and it may become a powerful tool to manipulate gene expression experimentally. RNAi technology is currently being evaluated not only as an extremely powerful instrument for functional genomic analyses, but also as a potentially useful method to develop specific dsRNA based gene-silencing therapeutics. Several laboratories have been interested in using RNAi to control viral infection and many reports in Nature and in Cell show that short interfering (si) RNAs can inhibit infection by HIV-1, polio and hepatitis C viruses in a sequence-specific manner. RNA-based strategies for gene inhibition in mammalian cells have recently been described, which offer the promise of antiviral therapy.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.