ArticleDevelopmental psychobiology2003
Modification of bitter taste in children.
Article in Developmental psychobiology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 58 citations in OpenAlex.
- In situ coating makes it easier for children to swallow and tolerate tablets and capsules.Acta paediatrica (Oslo, Norway : 1992) · 2015Trial
- Trial
- Personal variation in the palatability and side effects of liquid clindamycin among children.Pediatric research · 2026Article
- Genetic influences on diet in young Swedish adults: a twin study.The American journal of clinical nutrition · 2026Article
- Discovery of bitter masking compounds from Allspice (Food chemistry: X · 2024Article
- Parents' perspective on recovery at home following adenotonsillectomy: a prospective single-centre qualitative analysis.Canadian journal of anaesthesia = Journal canadien d'anesthesie · 2023Observational
- Taste Perceptions of Common Pediatric Antibiotic Suspensions and Associated Prescribing Patterns in Medical Residents.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2022Article
- A chewable pediatric preparation of ibuprofen is palatable and acceptable to children.Paediatric & neonatal pain · 2020Article
- The Influence of Taste Liking on the Consumption of Nutrient Rich and Nutrient Poor Foods.Frontiers in nutrition · 2019Review
- Review
- Flavour preferences in youth versus adults: a review.Tobacco control · 2016Review
- The sweetness and bitterness of childhood: Insights from basic research on taste preferences.Physiology & behavior · 2015Review
- "A spoonful of sugar helps the medicine go down": bitter masking by sucrose among children and adults.Chemical senses · 2015Article
- Human bitter perception correlates with bitter receptor messenger RNA expression in taste cells.The American journal of clinical nutrition · 2013Article
- The bad taste of medicines: overview of basic research on bitter taste.Clinical therapeutics · 2013Review
- Masking Vegetable Bitterness to Improve Palatability Depends on Vegetable Type and Taste Phenotype.Chemosensory perception · 2013Article
- Optimizing oral medications for children.Clinical therapeutics · 2008Review
- Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The palatability of oral medications, many of which are quite bitter, plays an important role in achieving compliance in pediatric patients. We tested the hypothesis that the addition of a sodium salt to some, but not all, bitter tasting liquids enhances acceptance and reduces the perceived bitterness in 7- to 10-year-old children and their mothers. For both children and adults, sodium gluconate significantly suppressed the perceived bitterness and enhanced the acceptance of urea and caffeine whereas the reverse was true for another bitter stimulus, Tetralone. Because children preferred salted solutions more than did adults, these data suggest that the use of sodium salts may be an especially effective strategy for reducing the bitterness of some medicines and facilitating compliance among pediatric populations. However, based on sodium's differential ability to inhibit bitterness, as has been shown here with children and adults, clearly each drug of interest must be evaluated separately.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.