SynthesisThe Cochrane database of systematic reviews2003
Ketogenic diet for epilepsy.
Synthesis in The Cochrane database of systematic reviews, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00552526 (Comparing Ketogenic Diet With the Most Appropriate Antiepileptic Drug- a Randomized Study of Children With Mental Retardation and Drug Resistant Epilepsy), which is not on this map. Cited by 17 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Comparing Ketogenic Diet With the Most Appropriate Antiepileptic Drug- a Randomized Study of Children With Mental Retardation and Drug Resistant Epilepsy
Who cites it
17 citing papers in PubMed, 3 syntheses or guidelines pooled it, 79 citations in OpenAlex.
- Ketogenic diets for drug-resistant epilepsy.The Cochrane database of systematic reviews · 2020Pooled it
- Ketogenic diet for the treatment of pediatric epilepsy: review and meta-analysis.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2020Pooled it
- Ketogenic diets for drug-resistant epilepsy.The Cochrane database of systematic reviews · 2018Pooled it
- Research into the (Cost-) effectiveness of the ketogenic diet among children and adolescents with intractable epilepsy: design of a randomized controlled trial.BMC neurology · 2011Trial
- A Ketogenic Diet Improves Mitochondrial Biogenesis and Bioenergetics via the PGC1α-SIRT3-UCP2 Axis.Neurochemical research · 2019Article
- Diabetes and epilepsy in children and adolescents.Current diabetes reports · 2015Review
- CAM use in pediatric neurology: an exploration of concurrent use with conventional medicine.PloS one · 2014Article
- Ketogenic diet in epileptic encephalopathies.Epilepsy research and treatment · 2013Article
- Dietary therapies for epilepsy: future research.Epilepsy & behavior : E&B · 2011Review
- Ketogenic diet for treatment of epilepsy.Canadian family physician Medecin de famille canadien · 2010Article
- Management of the patient with medically refractory epilepsy.Expert review of neurotherapeutics · 2009Review
- Treatment of Lennox-Gastaut syndrome: overview and recent findings.Neuropsychiatric disease and treatment · 2008Article
- Case report: scurvy in an epileptic child on a ketogenic diet with oral complications.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2008Article
- Alternative approaches to conventional antiepileptic drugs in the management of paediatric epilepsy.Archives of disease in childhood · 2006Review
- Calorie restriction extends life span--but which calories?PLoS medicine · 2005Article
- First Application of Ketogenic Diet on a Child With Intractable Epilepsy in Ghana.Child neurology openArticle
- Article
Corrections and comments
- Updated by
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe ketogenic diet is a diet high in fat but low in carbohydrate and it is suggested that this diet reduces seizure frequency. Currently, this diet is used mainly for children who continue to have seizures despite treatment with antiepileptic drugs.
objectivesTo overview the evidence from randomized controlled trials regarding the effects of ketogenic diets. SEARCH STRATEGY: We searched the Cochrane Epilepsy Group trials register (26 March 2003), the Cochrane Central Register of Controlled Trials (The Cochrane Library issue 1, 2003), MEDLINE (January 1966 to March 2003) and EMBASE (1980 to March 2003). SELECTION CRITERIA: Randomized controlled trials of ketogenic diets for people with epilepsy. DATA COLLECTION AND ANALYSIS: We planned for two reviewers to independently apply inclusion criteria and extract data. MAIN
resultsNo randomized controlled trials were found. REVIEWER'S
conclusionsThere is no reliable evidence from randomized controlled trials to support the use of ketogenic diets for people with epilepsy. There are large observational studies, some prospective, suggesting an effect on seizures. These effects need validating in randomized controlled trials. For those with a difficult epilepsy on multiple antiepileptic drugs, we consider the ketogenic diet a possible option.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.