ArticleOncogene2003
Overexpression of ErbB2 enhances ethanol-stimulated intracellular signaling and invasion of human mammary epithelial and breast cancer cells in vitro.
Article in Oncogene, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 51 citations in OpenAlex.
- Alcohol and breast cancer.Pharmacological reports : PR · 2023Review
- Alcohol and Cancer Stem Cells.Cancers · 2017Review
- Cellular and molecular mechanisms underlying alcohol-induced aggressiveness of breast cancer.Pharmacological research · 2017Review
- Role of cytokines and chemokines in alcohol-induced tumor promotion.OncoTargets and therapy · 2017Review
- Long-term exposure of MCF-7 breast cancer cells to ethanol stimulates oncogenic features.International journal of oncology · 2017Article
- ErbB2 and p38γ MAPK mediate alcohol-induced increase in breast cancer stem cells and metastasis.Molecular cancer · 2016Article
- Alcohol consumption and risk of breast cancer by molecular subtype: Prospective analysis of the nurses' health study after 26 years of follow-up.International journal of cancer · 2016Article
- Chronic ethanol exposure enhances the aggressiveness of breast cancer: the role of p38γ.Oncotarget · 2016Article
- Activation of the NF-κB pathway as a mechanism of alcohol enhanced progression and metastasis of human hepatocellular carcinoma.Molecular cancer · 2015Article
- Effects of Alcohol on Tumor Growth, Metastasis, Immune Response, and Host Survival.Alcohol research : current reviews · 2015Review
- Butein suppresses breast cancer growth by reducing a production of intracellular reactive oxygen species.Journal of experimental & clinical cancer research : CR · 2014Article
- MT1-MMP in breast cancer: induction of VEGF-C correlates with metastasis and poor prognosis.Cancer cell international · 2013Article
- Chemical principles for the design of a novel fluorescent probe with high cancer-targeting selectivity and sensitivity.Integrative biology : quantitative biosciences from nano to macro · 2013Article
- ERα mediates alcohol-induced deregulation of Pol III genes in breast cancer cells.Carcinogenesis · 2013Article
- Ethanol disrupts vascular endothelial barrier: implication in cancer metastasis.Toxicological sciences : an official journal of the Society of Toxicology · 2012Article
- Alcohol consumption in relation to aberrant DNA methylation in breast tumors.Alcohol (Fayetteville, N.Y.) · 2011Article
- Inhibition of Epidermal Growth Factor Receptor and PI3K/Akt Signaling Suppresses Cell Proliferation and Survival through Regulation of Stat3 Activation in Human Cutaneous Squamous Cell Carcinoma.Journal of skin cancer · 2011Article
- Cyanidin-3-glucoside inhibits ethanol-induced invasion of breast cancer cells overexpressing ErbB2.Molecular cancer · 2010Article
- ErbB4 signals Neuregulin1-stimulated cell proliferation and c-fos gene expression through phosphorylation of serum response factor by mitogen-activated protein kinase cascade.Molecular and cellular biochemistry · 2010Article
- Ethanol enhances the interaction of breast cancer cells over-expressing ErbB2 with fibronectin.Alcoholism, clinical and experimental research · 2010Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
Both epidemiological and experimental studies indicate that ethanol is a tumor promoter and may promote metastasis of breast cancer. However, the molecular mechanisms underlying ethanol-mediated tumor promotion remain unknown. Overexpression of ErbB proteins in breast cancer patients is generally associated with poor prognosis. The ErbB proteins are a family of receptor kinases that include four closely related members: epidermal growth factor receptor (EGFR/ErbB1), ErbB2/neu, ErbB3, and ErbB4. Particularly, ErbB2 plays a pivotal role in ErbB-mediated activities. Here we demonstrated that amplification of ErbB2 expression sensitized a specific cellular response to ethanol. Human breast cancer cells or mammary epithelial cells with a high expression of ErbB2 exhibited an enhanced response to ethanol-stimulated cell invasion in vitro. Ethanol also stimulated cell proliferation; however, this stimulation was independent of ErbB2 levels. Ethanol triggered divergent intracellular signaling among cells expressing different ErbB2 levels. In the cells overexpressing ErbB2, ethanol was more effective in the activation of c-Jun NH2 terminal protein kinases (JNKs) and p38 mitogen-activated protein kinase (p38 MAPK) as well as the induction of reactive oxygen species (ROS) than the cells with normal ErbB2 expression. Blockage of either JNKs or p38 MAPK activation eliminated ethanol-mediated cell invasion. In contrast, the reduction of hydrogen peroxide concentration by catalase exposure had little effect on ethanol-induced cell invasion. These results indicated that ethanol-induced cell invasion was primarily mediated by JNKs and p38 MAPK, whereas the involvement of ROS formation might be minimal. Our study suggests that overexpression of ErbB2 may augment ethanol-elicited signaling and promote ethanol-stimulated tumor metastasis.
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