ArticleMolecular and cellular biology2003
The critical cis-acting element required for IMD2 feedback regulation by GDP is a TATA box located 202 nucleotides upstream of the transcription start site.
Article in Molecular and cellular biology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- In thePNAS nexus · 2026Article
- GTP-dependent regulation of heterochromatin fluctuations at subtelomeric regions in Saccharomyces cerevisiae.Genes to cells : devoted to molecular & cellular mechanisms · 2024Article
- Regulation of amino acid, nucleotide, and phosphate metabolism in Saccharomyces cerevisiae.Genetics · 2012Article
- Yeast Pol II start-site selection: the long and the short of it.EMBO reports · 2008Article
- Mutations of RNA polymerase II activate key genes of the nucleoside triphosphate biosynthetic pathways.The EMBO journal · 2008Article
- Properties of an intergenic terminator and start site switch that regulate IMD2 transcription in yeast.Molecular and cellular biology · 2008Article
- Functions of Saccharomyces cerevisiae TFIIF during transcription start site utilization.Molecular and cellular biology · 2008Article
- Lethal accumulation of guanylic nucleotides in Saccharomyces cerevisiae HPT1-deregulated mutants.Genetics · 2008Article
- Metabolic regulation of IMD2 transcription and an unusual DNA element that generates short transcripts.Molecular and cellular biology · 2007Article
- Accumulation of unstable promoter-associated transcripts upon loss of the nuclear exosome subunit Rrp6p in Saccharomyces cerevisiae.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Mapping of transcription start sites in Saccharomyces cerevisiae using 5' SAGE.Nucleic acids research · 2005Article
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3 authors.
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Abstract
Guanylic nucleotides are essential cellular players, and the critical enzyme in their tightly regulated synthesis in Saccharomyces cerevisiae is encoded by the IMD2 gene. The transcription of IMD2 is subject to general repression by nutrient limitation through the cis nutrient-sensing element. It is also subject to specific feedback regulation by the end products of the guanylic nucleotide synthesis pathway. The critical cis element for this latter mechanism is the guanine response element (GRE), a TATAATA sequence which is located 202 nucleotides upstream of the transcription initiation site and which functions as the IMD2 TATA box. We show that the GRE functions in conjunction with a 52-nucleotide stretch near the transcription start site. This very unusual promoter structure ensures low, basal expression of IMD2 and the recruitment of TFIID to the GRE in response to guanylic nucleotide limitation.
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