ArticleAmerican journal of human genetics2003
Assessing the performance of the haplotype block model of linkage disequilibrium.
Article in American journal of human genetics, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
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Who cites it
50 citing papers in PubMed, 150 citations in OpenAlex.
- Extended linkage disequilibrium surrounding the hemoglobin E variant due to malarial selection.American journal of human genetics · 2004Trial
- The impact of sample size and marker selection on the study of haplotype structures.Human genomics · 2004Trial
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- A new haplotype block detection method for dense genome sequencing data based on interval graph modeling of clusters of highly correlated SNPs.Bioinformatics (Oxford, England) · 2018Article
- A novel haplotype of low-frequency variants in the aldosterone synthase gene among northern Han Chinese with essential hypertension.Medicine · 2017Article
- Drosophila and genome-wide association studies: a review and resource for the functional dissection of human complex traits.Disease models & mechanisms · 2017Review
- Effects of Single Nucleotide Polymorphism Marker Density on Haplotype Block Partition.Genomics & informatics · 2016Article
- Cloud computing-based TagSNP selection algorithm for human genome data.International journal of molecular sciences · 2015Article
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- Sub-genomic selection patterns as a signature of breeding in the allopolyploid Brassica napus genome.BMC genomics · 2014Article
- Aldehyde dehydrogenase variation enhances effect of pesticides associated with Parkinson disease.Neurology · 2014Article
- Pooled analysis of iron-related genes in Parkinson's disease: association with transferrin.Neurobiology of disease · 2014Article
- Efficient haplotype block recognition of very long and dense genetic sequences.BMC bioinformatics · 2014Article
- Computer simulations: tools for population and evolutionary genetics.Nature reviews. Genetics · 2012Review
- Genome-wide analysis shows increased frequency of copy number variation deletions in Dutch schizophrenia patients.Biological psychiatry · 2011Article
- BLOCK-BASED BAYESIAN EPISTASIS ASSOCIATION MAPPING WITH APPLICATION TO WTCCC TYPE 1 DIABETES DATA.The annals of applied statistics · 2011Article
- Characteristics of eight X-STR loci for forensic purposes in the Chinese population.International journal of legal medicine · 2011Article
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- A multilocus linkage disequilibrium measure based on mutual information theory and its applications.Genetica · 2009Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Several recent studies have suggested that linkage disequilibrium (LD) in the human genome has a fundamentally "blocklike" structure. However, thus far there has been little formal assessment of how well the haplotype block model captures the underlying structure of LD. Here we propose quantitative criteria for assessing how blocklike LD is and apply these criteria to both real and simulated data. Analyses of several large data sets indicate that real data show a partial fit to the haplotype block model; some regions conform quite well, whereas others do not. Some improvement could be obtained by genotyping higher marker densities but not by increasing the number of samples. Nonetheless, although the real data are only moderately blocklike, our simulations indicate that, under a model of uniform recombination, the structure of LD would actually fit the block model much less well. Simulations of a model in which much of the recombination occurs in narrow hotspots provide a much better fit to the observed patterns of LD, suggesting that there is extensive fine-scale variation in recombination rates across the human genome.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.