ArticleJournal of virology2003
High circulating frequencies of tumor necrosis factor alpha- and interleukin-2-secreting human T-lymphotropic virus type 1 (HTLV-1)-specific CD4+ T cells in patients with HTLV-1-associated neurological disease.
Article in Journal of virology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed.
- Safety and efficacy of teriflunomide on clinical course, and laboratory findings in patients with HTLV-1-associated myelopathy/tropical spastic paraparesis: a triple-blind study.Journal of neurology · 2025Trial
- Complete Rescue of HTLV-1Pathogens (Basel, Switzerland) · 2024Article
- NK cells and monocytes modulate primary HTLV-1 infection.PLoS pathogens · 2022Article
- The effect of HTLV1 infection on inflammatory and oxidative parameters in the liver, kidney, and pancreases of BALB/c mice.Physiological reports · 2022Article
- Tocilizumab has no direct effect on cell lines infected with human T-cell leukemia virus type 1.The Journal of international medical research · 2021Article
- Neuroimmunology of Human T-Lymphotropic Virus Type 1-Associated Myelopathy/Tropical Spastic Paraparesis.Frontiers in microbiology · 2019Review
- Interactions between inflammatory gene polymorphisms and HTLV-I infection for total death, incidence of cancer, and atherosclerosis-related diseases among the Japanese population.Journal of epidemiology · 2017Article
- The Predominant CD4Clinical and vaccine immunology : CVI · 2017Article
- Tumor necrosis factor alpha inhibitors have no effect on a human T-lymphotropic virus type-I (HTLV-I)-infected cell line from patients with HTLV-I-associated myelopathy.BMC immunology · 2017Article
- Effect of Pulsed Methylprednisolone on Pain, in Patients with HTLV-1-Associated Myelopathy.PloS one · 2016Article
- Neuroimmunological aspects of human T cell leukemia virus type 1-associated myelopathy/tropical spastic paraparesis.Journal of neurovirology · 2014Review
- The Impact of Immune Response on HTLV-I in HTLV-I-Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP).Iranian journal of basic medical sciences · 2013Article
- Human T Lymphotropic Virus Type I (HTLV-I) is a Risk Factor for Coronary Artery Disease.Iranian journal of basic medical sciences · 2013Article
- Human endogenous retrovirus K(HML-2) Gag and Env specific T-cell responses are not detected in HTLV-I-infected subjects using standard peptide screening methods.Journal of negative results in biomedicine · 2013Article
- A transgenic mouse model of human T cell leukemia virus type 1-associated diseases.Frontiers in microbiology · 2013Article
- Immunological profile of HTLV-1-infected patients associated with infectious or autoimmune dermatological disorders.PLoS neglected tropical diseases · 2013Article
- Helminthic infection and the risk of neurologic disease progression in HTLV-1.Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology · 2012Article
- Minocycline modulates antigen-specific CTL activity through inactivation of mononuclear phagocytes in patients with HTLV-I associated neurologic disease.Retrovirology · 2012Article
- Pathogenesis of Metastatic Calcification and Acute Pancreatitis in Adult T-Cell Leukemia under Hypercalcemic State.Leukemia research and treatment · 2012Article
- Ascorbic acid has superior ex vivo antiproliferative, cell death-inducing and immunomodulatory effects over IFN-α in HTLV-1-associated myelopathy.PLoS neglected tropical diseases · 2012Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
Significantly higher frequencies of tumor necrosis factor alpha- and interleukin-2-secreting human T-lymphotropic virus type 1 (HTLV-1)-specific CD4(+) T cells were present in the peripheral blood mononuclear cells of HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) patients than in those of asymptomatic carriers with similar provirus loads. The data suggest that HTLV-1-specific CD4(+) T cells play a role in the pathogenesis of HAM/TSP.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.