ArticleJournal of virology2003
Epidemiology, genetic diversity, and evolution of endemic feline immunodeficiency virus in a population of wild cougars.
Article in Journal of virology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
36 citing papers in PubMed, 1 synthesis or guideline pooled it, 78 citations in OpenAlex.
- Variation in Intra-individual Lentiviral Evolution Rates: a Systematic Review of Human, Nonhuman Primate, and Felid Species.Journal of virology · 2019Pooled it
- Hunting alters viral transmission and evolution in a large carnivore.Nature ecology & evolution · 2022Article
- Equal contributions of feline immunodeficiency virus and coinfections to morbidity in African lions.International journal for parasitology. Parasites and wildlife · 2021Article
- Host relatedness and landscape connectivity shape pathogen spread in the puma, a large secretive carnivore.Communications biology · 2021Article
- Does the virus cross the road? Viral phylogeographic patterns among bobcat populations reflect a history of urban development.Evolutionary applications · 2020Article
- Altered lentiviral infection dynamics follow genetic rescue of the Florida panther.Proceedings. Biological sciences · 2019Article
- Feline immunodeficiency virus in puma: Estimation of force of infection reveals insights into transmission.Ecology and evolution · 2019Article
- Time-Dependent Rate Phenomenon in Viruses.Journal of virology · 2016Article
- Species-specific differences in the ability of feline lentiviral Vif to degrade feline APOBEC3 proteins.Microbiology and immunology · 2016Article
- Infectious disease transmission and contact networks in wildlife and livestock.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2015Review
- Rapid evolution of the env gene leader sequence in cats naturally infected with feline immunodeficiency virus.The Journal of general virology · 2015Article
- Evolution of puma lentivirus in bobcats (Lynx rufus) and mountain lions (Puma concolor) in North America.Journal of virology · 2014Article
- Novel gammaherpesviruses in North American domestic cats, bobcats, and pumas: identification, prevalence, and risk factors.Journal of virology · 2014Article
- Emerging viruses in the Felidae: shifting paradigms.Viruses · 2012Review
- Antagonistic pleiotropy and fitness trade-offs reveal specialist and generalist traits in strains of canine distemper virus.PloS one · 2012Article
- Evolution and phylogeography of the nonpathogenic calicivirus RCV-A1 in wild rabbits in Australia.Journal of virology · 2010Article
- Spatial analysis of feline immunodeficiency virus infection in cougars.Spatial and spatio-temporal epidemiology · 2010Article
- Molecular epidemiology of feline immunodeficiency virus in the domestic cat (Felis catus).Veterinary immunology and immunopathology · 2010Review
- Restrictions to cross-species transmission of lentiviral infection gleaned from studies of FIV.Veterinary immunology and immunopathology · 2010Review
- Multivariate statistical analyses demonstrate unique host immune responses to single and dual lentiviral infection.PloS one · 2009Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Within the large body of research on retroviruses, the distribution and evolution of endemic retroviruses in natural host populations have so far received little attention. In this study, the epidemiology, genetic diversity, and molecular evolution of feline immunodeficiency virus specific to cougars (FIVpco) was examined using blood samples collected over several years from a free-ranging cougar population in the western United States. The virus prevalence was 58% in this population (n = 52) and increased significantly with host age. Based on phylogenetic analysis of fragments of envelope (env) and polymerase (pol) genes, two genetically distinct lineages of FIVpco were found to cooccur in the population but not in the same individuals. Within each of the virus lineages, geographically nearby isolates formed monophyletic clusters of closely related viruses. Sequence diversity for env within a host rarely exceeded 1%, and the evolution of this gene was dominated by purifying selection. For both pol and env, our data indicate mean rates of molecular evolution of 1 to 3% per 10 years. These results support the premise that FIVpco is well adapted to its cougar host and provide a basis for comparing lentivirus evolution in endemic and epidemic infections in natural hosts.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.