ArticleThe Biochemical journal2003
Modulation of NAADP (nicotinic acid-adenine dinucleotide phosphate) receptors by K+ ions: evidence for multiple NAADP receptor conformations.
Article in The Biochemical journal, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 41 citations in OpenAlex.
- NAADP-Dependent TPC Current.Handbook of experimental pharmacology · 2023Article
- NAADP Receptors.Cold Spring Harbor perspectives in biology · 2019Review
- Mining of Ebola virus entry inhibitors identifies approved drugs as two-pore channel pore blockers.Biochimica et biophysica acta. Molecular cell research · 2019Article
- Two-pore channels provide insight into the evolution of voltage-gated Ca2+ and Na+ channels.Science signaling · 2014Article
- Nicotinic acid adenine dinucleotide phosphate (NAADP) is a second messenger in muscarinic receptor-induced contraction of guinea pig trachea.The Journal of biological chemistry · 2013Article
- The Molecular Basis for CaMessenger (Los Angeles, Calif. : Print) · 2012Article
- Photoaffinity labeling of high affinity nicotinic acid adenine dinucleotide phosphate (NAADP)-binding proteins in sea urchin egg.The Journal of biological chemistry · 2012Article
- The endo-lysosomal system as an NAADP-sensitive acidic Ca(2+) store: role for the two-pore channels.Cell calcium · 2011Review
- Two-pore channels: Regulation by NAADP and customized roles in triggering calcium signals.Cell calcium · 2010Review
- Purified TPC isoforms form NAADP receptors with distinct roles for Ca(2+) signaling and endolysosomal trafficking.Current biology : CB · 2010Article
- Article
- Time sensing by NAADP receptors.The Biochemical journal · 2006Article
- NAADP binding to its target protein in sea urchin eggs requires phospholipids.The Biochemical journal · 2005Article
- Triazine dyes are agonists of the NAADP receptor.British journal of pharmacology · 2004Article
- The NAADP receptor: commentary on Billington et al.British journal of pharmacology · 2004Review
- Determination of cellular nicotinic acid-adenine dinucleotide phosphate (NAADP) levels.The Biochemical journal · 2004Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
NAADP (nicotinic acid-adenine dinucleotide phosphate) mediates Ca2+ release from intracellular Ca2+ stores in a wide variety of cell types. In sea urchin eggs, subthreshold concentrations of NAADP can cause full inactivation of NAADP-induced Ca2+ release, an effect that may be related to the ability of the target protein to bind its ligand in an essentially irreversible manner. In the present study, we found that K+ ions inhibit dissociation of NAADP from sea urchin egg homogenates. In low K+-containing media, an addition of excess unlabelled NAADP effectively displaced bound radioligand whereas dilution of radioligand initiated only partial dissociation. The inhibitory effects of K+ on dissociation of NAADP were concentration dependent, reversible and persisted after detergent solubilization. Lowering [K+] of the medium decreased the sensitivity of NAADP receptors for their ligand in stimulating Ca2+ release, but it did not affect inactivation of NAADP-induced Ca2+ release by subthreshold concentrations of NAADP. Our results are consistent with the observation of multiple conformations of the NAADP receptor that are readily revealed in low K+-containing media.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.