ArticleEukaryotic cell2003
Roles of Candida albicans Dfg5p and Dcw1p cell surface proteins in growth and hypha formation.
Article in Eukaryotic cell, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.
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Who cites it
60 citing papers in PubMed.
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- Integrated post-genomic cell wall analysis reveals floating biofilm formation associated with high expression of flocculins in the pathogen Pichia kudriavzevii.PLoS pathogens · 2023Article
- Extracellular targeting of Neurospora crassa cell wall and secreted glycoproteins by DFG-5.Fungal genetics and biology : FG & B · 2022Article
- Fungal Cell Wall Proteins and Signaling Pathways Form a Cytoprotective Network to Combat Stresses.Journal of fungi (Basel, Switzerland) · 2021Review
- The protein kinase Ire1 impacts pathogenicity of Candida albicans by regulating homeostatic adaptation to endoplasmic reticulum stress.Cellular microbiology · 2021Article
- Effects of Simulated Microgravity on the Proteome and Secretome of the Polyextremotolerant Black FungusFrontiers in genetics · 2021Article
- The GPI-Anchored GH76 Protein Dfg5 Affects Hyphal Morphology and Osmoregulation in the MycoparasiteFrontiers in microbiology · 2021Article
- Evolutionary Overview of Molecular Interactions and Enzymatic Activities in the Yeast Cell Walls.International journal of molecular sciences · 2020Review
- Structural base for the transfer of GPI-anchored glycoproteins into fungal cell walls.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Copper-only superoxide dismutase enzymes and iron starvation stress inThe Journal of biological chemistry · 2020Article
- An Erg11 lanosterol 14-α-demethylase-Arv1 complex is required for Candida albicans virulence.PloS one · 2020Article
- The Glycosylphosphatidylinositol-AnchoredmSphere · 2019Article
- Role of Protein Mannosylation in theFrontiers in microbiology · 2019Article
- The Genetics and Biochemistry of Cell Wall Structure and Synthesis inFrontiers in microbiology · 2019Review
- Functions ofPeerJ · 2018Article
- Proteomic analysis of a Candida albicans pir32 null strain reveals proteins involved in adhesion, filamentation and virulence.PloS one · 2018Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
The Candida albicans cell wall participates in both growth and morphological transitions between yeast and hyphae. Our studies here focus on Dfg5p and Dcw1p, two similar proteins with features of glycosylphosphatidylinositol-linked cell surface proteins. Mutants lacking Dfg5p are defective in alkaline pH-induced hypha formation; mutants lacking Dcw1p have no detected hypha formation defect. Both homozygote-triplication tests and conditional expression strategies indicate that dfg5 and dcw1 mutations are synthetically lethal. Therefore, Dfg5p and Dcw1p share a function required for growth. Epitope-tagged Dfg5p, created through an insertional mutagenesis strategy, is found in cell membrane and cell wall extract fractions, and endoglycosidase H digestion shows that Dfg5p undergoes N-linked mannosylation. Surprisingly, Dfg5p is required for expression of the hypha-specific gene HWP1 in alkaline media. Because Dfg5p is a cell surface protein, it is poised to generate or transmit an external signal required for the program of hypha-specific gene expression.
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