ArticleGut2003
Immunomodulatory effects of inhaled carbon monoxide on rat syngeneic small bowel graft motility.
Article in Gut, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
37 citing papers in PubMed, 98 citations in OpenAlex.
- Compelling Evidence: A Critical Update on the Therapeutic Potential of Carbon Monoxide.Medicinal research reviews · 2025Review
- Plight of CORMs: The unreliability of four commercially available CO-releasing molecules, CORM-2, CORM-3, CORM-A1, and CORM-401, in studying CO biology.Biochemical pharmacology · 2023Review
- Role of Heme Oxygenase in Gastrointestinal Epithelial Cells.Antioxidants (Basel, Switzerland) · 2022Review
- Muscularis macrophages: Key players in intestinal homeostasis and disease.Cellular immunology · 2018Review
- Microbiome and intestinal ischemia/reperfusion injury.Journal of clinical biochemistry and nutrition · 2018Review
- Heat shock proteins and kidney disease: perspectives of HSP therapy.Cell stress & chaperones · 2017Review
- Carbon monoxide decreases interleukin-1β levels in the lung through the induction of pyrin.Cellular & molecular immunology · 2017Article
- The Protective Role of Carbon Monoxide (CO) Produced by Heme Oxygenases and Derived from the CO-Releasing Molecule CORM-2 in the Pathogenesis of Stress-Induced Gastric Lesions: Evidence for Non-Involvement of Nitric Oxide (NO).International journal of molecular sciences · 2016Article
- Cytoprotective role of heme oxygenase-1 in liver ischemia reperfusion injury.International journal of clinical and experimental medicine · 2015Review
- Exogenous carbon monoxide suppresses Escherichia coli vitality and improves survival in an Escherichia coli-induced murine sepsis model.Acta pharmacologica Sinica · 2014Article
- The CO donor CORM-2 inhibits LPS-induced vascular cell adhesion molecule-1 expression and leukocyte adhesion in human rheumatoid synovial fibroblasts.British journal of pharmacology · 2014Article
- Review article: carbon monoxide in gastrointestinal physiology and its potential in therapeutics.Alimentary pharmacology & therapeutics · 2013Review
- Heme oxygenase-1 and gut ischemia/reperfusion injury: A short review.World journal of gastroenterology · 2013Review
- Heme oxygenase-1 deficiency promotes the development of necrotizing enterocolitis-like intestinal injury in a newborn mouse model.American journal of physiology. Gastrointestinal and liver physiology · 2013Article
- The immunomodulatory role of carbon monoxide during transplantation.Medical gas research · 2013Article
- Article
- Therapeutic applications of carbon monoxide.Oxidative medicine and cellular longevity · 2013Review
- Role of interleukin-6 in hemopoietic and non-hemopoietic synergy mediating TLR4-triggered late murine ileus and endotoxic shock.Neurogastroenterology and motility · 2012Article
- Use of carbon monoxide in minimizing ischemia/reperfusion injury in transplantation.Transplantation reviews (Orlando, Fla.) · 2012Review
- Dietary kaempferol suppresses inflammation of dextran sulfate sodium-induced colitis in mice.Digestive diseases and sciences · 2012Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
backgroundIntestinal transplantation provokes an intense inflammatory response within the graft muscularis that causes intestinal ileus. We hypothesised that endogenously produced anti-inflammatory substances could be utilised as novel therapeutics. Therefore, we tested the protective effects of inhaled carbon monoxide (CO) and an endogenous haeme oxygenase 1 (HO-1) anti-inflammatory mediator on transplant induced inflammatory responses and intestinal ileus in the rat.
methodsGastrointestinal transit of non-absorbable FITC labelled dextran and in vitro jejunal circular muscle contractions were measured in controls and syngeneic orthotopic transplanted animals with and without CO inhalation (250 ppm for 25 hours). Inflammatory mRNAs for interleukin (IL)-6, IL-1beta, tumour necrosis factor alpha (TNF-alpha), intercellular adhesion molecule 1 (ICAM-1), inducible nitric oxide (iNOS), cyclooxygenase 2 (COX-2), and IL-10 were quantified by real time reverse transcriptase-polymerase chain reaction and HO-1 by northern blot. Histochemical stains characterised neutrophil infiltration and enterocyte apoptosis.
resultsTransplantation delayed transit and suppressed jejunal circular muscle contractility. Transplantation induced dysmotility was significantly improved by CO inhalation. Transplantation initiated a significant upregulation in IL-6, IL-1beta, TNF-alpha, ICAM-1, iNOS, COX-2, and HO-1 mRNAs with the graft muscularis. CO inhalation significantly decreased expression of IL-6, IL-1beta, iNOS, and COX-2 mRNAs. CO also significantly decreased serum nitrite levels (iNOS activity).
conclusionsCO inhalation significantly improved post-transplant motility and attenuated the inflammatory cytokine milieu in the syngeneic rat transplant model. Thus clinically providing CO, the end product of the anti-inflammatory HO-1 pathway, may prove to be an effective therapeutic adjunct for clinical small bowel transplantation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.