ArticleChromosoma1992
A human DNA replication origin: localization and transcriptional characterization.
Article in Chromosoma, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 44 citations in OpenAlex.
- Genome-wide identification and characterisation of human DNA replication origins by initiation site sequencing (ini-seq).Nucleic acids research · 2016Article
- Peaks cloaked in the mist: the landscape of mammalian replication origins.The Journal of cell biology · 2015Review
- Differential chromatin structure encompassing replication origins in transformed and normal cells.Genes & cancer · 2012Article
- Genomic study of replication initiation in human chromosomes reveals the influence of transcription regulation and chromatin structure on origin selection.Molecular biology of the cell · 2010Article
- The Mre11 complex mediates the S-phase checkpoint through an interaction with replication protein A.Molecular and cellular biology · 2007Article
- Specific signals at the 3' end of the DHFR gene define one boundary of the downstream origin of replication.Genes & development · 2005Article
- The human beta-globin replication initiation region consists of two modular independent replicators.Molecular and cellular biology · 2004Article
- Site-specific and temporally controlled initiation of DNA replication in a human cell-free system.Nucleic acids research · 2002Article
- Identification of a binding region for human origin recognition complex proteins 1 and 2 that coincides with an origin of DNA replication.Molecular and cellular biology · 2002Article
- Enhanced flexibility and aphidicolin-induced DNA breaks near mammalian replication origins: implications for replicon mapping and chromosome fragility.Nucleic acids research · 2000Article
- Interference of the simian virus 40 origin of replication by the cytomegalovirus immediate early gene enhancer: evidence for competition of active regulatory chromatin conformation in a single domain.Molecular and cellular biology · 2000Article
- oriGNAI3: a narrow zone of preferential replication initiation in mammalian cells identified by 2D gel and competitive PCR replicon mapping techniques.Nucleic acids research · 1998Article
- Precise switching of DNA replication timing in the GC content transition area in the human major histocompatibility complex.Molecular and cellular biology · 1997Article
- Transcription and polyadenylation in a short human intergenic region.Nucleic acids research · 1997Article
- Induction of DNA replication by transcription in the region upstream of the human c-myc gene in a model replication system.Molecular and cellular biology · 1996Article
- High-resolution mapping of the origin of DNA replication in the hamster dihydrofolate reductase gene domain by competitive PCR.Molecular and cellular biology · 1996Article
- Utilization of the same DNA replication origin by human cells of different derivation.Nucleic acids research · 1996Article
- In vivo protein-DNA interactions at human DNA replication origin.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
- Mapping of replication initiation sites in human ribosomal DNA by nascent-strand abundance analysis.Molecular and cellular biology · 1995Article
- Molecular and functional interactions of transcription factor USF with the long terminal repeat of human immunodeficiency virus type 1.Journal of virology · 1995Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A single-copy 13.7 kb human DNA region (L30E) located on Ch. 19 p13.3 contains an origin of DNA replication in myeloid HL-60 cells. The origin was localized, by means of quantitative PCR within approximately 3000 bp, in a highly transcribed region containing at least two closely spaced genes with the same polarity of transcription, one encoding lamin B2 and the other an unidentified protein. The origin region overlaps an undermethylated "CpG island" at the 5'-end of the second transcription unit. A binding site (CACGTG) for basic helix-loop-helix (bHLH) DNA binding proteins such as USF/MLTF or MYC-MAX was located by DNase I footprinting analysis in the promoter of the second gene. DMSO differentiation of HL-60 cells, that completely shuts off replication, also drastically reduces the transcription of L30E region. On the other hand such treatment does not modify the methylation pattern of the CpG island and does not abolish the DNase I protection of the bHLH binding site.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.